Accumulation of a large component related to thyrotropin subunits in the pituitary of thyroidectomized rats
| Autor: | Gabriel Ponsin, R. Mornex, Chantal Poncet |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Macromolecular Substances Protein subunit Biophysics Radioimmunoassay Thyrotropin Biology Biochemistry chemistry.chemical_compound Biosynthesis Internal medicine β subunit medicine Animals Molecular Biology Α subunit RNA Cell Biology Rats Rat Pituitary Molecular Weight Kinetics Endocrinology chemistry Sephadex Pituitary Gland Thyroidectomy Hormone |
| Zdroj: | Biochemical and biophysical research communications. 89(4) |
| ISSN: | 0006-291X |
| Popis: | Rat pituitary thyrotropin-β subunit immunoreactivity is demonstrated to increase with time after thyroidectomy. This increase is due to free β subunits and a high molecular weight form. The latter is also immunoreactive in α subunit and native thyrotropin assays. Its immunological properties in these three types of assays respectively, suggest that it represents a “bid β subunit” and a “big α subunit” excluded together in Sephadex G-100 chromatography, rather than a “big thyrotropin”. These larger species could be precursor forms of the subunits. This would be in agreement with the concept of separate biosynthesis of the subunits of pituitary glycoproteic hormones. |
| Databáze: | OpenAIRE |
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