Influence of dexmedetomidine and lidocaine on perioperative opioid consumption in laparoscopic intestine resection: a randomized controlled clinical trial
| Autor: | Lea Andjelković, Vesna Novak-Jankovic, Zoran Bosnić, Neva Požar-Lukanović, Alenka Spindler-Vesel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Medicine (General) Lidocaine Clinical Research Reports Opioid consumption laparoscopy neuralgia Biochemistry Perioperative Care 03 medical and health sciences Intestine Resection R5-920 0302 clinical medicine 030202 anesthesiology Intestinal Neoplasms Humans Medicine Anesthetics Local Dexmedetomidine Laparoscopy cognitive function Aged Pain Measurement Aged 80 and over Pain Postoperative medicine.diagnostic_test business.industry Biochemistry (medical) dexmedetomidine Cell Biology General Medicine Perioperative Analgesics Non-Narcotic Middle Aged Opioid-Related Disorders Prognosis medicine.disease Analgesics Opioid Clinical trial Anesthesia Neuralgia Female Analgesia business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 46 (2018) |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060518792456 |
| Popis: | Objective The consumption of opioid analgesics could be reduced by the use of analgesics with different mechanisms of action. We investigated whether additional treatment with dexmedetomidine or lidocaine could reduce opioid consumption. Methods We randomized 59 study participants into three groups and examined: (i) fentanyl consumption, (ii) consumption of piritramide, and (iii) cognitive function and neuropathic pain. The control group received continuous propofol infusion and fentanyl boluses. Continuous intravenous infusion of dexmedetomidine (0.5 µg/kg/h) was administered to the dexmedetomidine group and lidocaine (1.5 mg/kg/h) was administered to the lidocaine group. Results No reduction in fentanyl consumption was observed among the groups. However, we noted a significantly lower consumption of piritramide on the first and second postoperative day in the lidocaine group. Total consumption of piritramide was significantly lower in the lidocaine group compared with the control group. Conclusions Lidocaine and dexmedetomidine reduced intraoperative propofol consumption, while lidocaine reduced postoperative piritramide consumption. Clinical trial registration: NCT02616523 |
| Databáze: | OpenAIRE |
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