Control of Patterns of Corneal Innervation by Pax6
| Autor: | Petr Walczysko, John D. West, Romana Kucerova, Lucy J. Leiper, Derek N. Lavery, Jingxing Ou, J. Martin Collinson |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Aging Effects of long-term contact lens wear on the cornea Pathology medicine.medical_specialty PAX6 Transcription Factor genetic structures Corneal epithelial cell migration Enzyme-Linked Immunosorbent Assay Substance P Biology Article Cornea Cellular and Molecular Neuroscience Mice Nerve Fibers Cell Movement Tubulin medicine Animals Paired Box Transcription Factors Eye Proteins Fluorescent Antibody Technique Indirect Corneal epithelium Homeodomain Proteins Mice Knockout Wound Healing Neurotrophic keratitis Epithelium Corneal Corneal Transplant medicine.disease Sensory Systems eye diseases Nerve Regeneration Repressor Proteins Ophthalmology medicine.anatomical_structure Trigeminal Ganglion Mice Inbred CBA Eye development Female sense organs Sensory nerve |
| Zdroj: | Leiper, L J, Ou, J X, Walczysko, P, Kucerova, R, Lavery, D N, West, J D & Collinson, J M 2009, ' Control of Patterns of Corneal Innervation by Pax6 ', Investigative Ophthalmology & Visual Science, vol. 50, no. 3, pp. 1122-1128 . https://doi.org/10.1167/iovs.08-2812 |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.08-2812 |
| Popis: | The transcription factor PAX6 is essential for eye development and is found in several ocular cell types, including the corneal and limbal epithelia, where gene expression is maintained throughout life.1-4 Heterozygous deficiencies in PAX6 are characterized by iris hypoplasia, corneal epithelial fragility, persistent lens-corneal bridge (Peter's anomaly) and corneal opacity, with vascularization and inflammation termed aniridic keratopathy or aniridia-related keratopathy (ARK).5-8 Mouse Pax6+/− corneas are an excellent model of human ARK.4,6,9-11 The corneal epithelium is one of the most densely innervated tissues of the body and receives sensory nerve fibers that originate principally in the trigeminal ganglion.12-14 The nerve bundles enter the corneal periphery radially to form the perilimbal ring.15 Bundles of fibers project and extend through the corneal stroma, subdivide, penetrate the anterior limiting lamina, and innervate the corneal epithelium, forming a basal epithelial nerve plexus.13,14 The mechanisms that control corneal epithelial nerve growth are incompletely known, but wound-induced electric currents have been shown to direct nerve regeneration after epithelial wounding.16 Corneal nerves maintain a healthy cornea through the release of soluble trophic factors.17,18 Substance P (SP) is of particular importance; it acts synergistically with other growth factors, including nerve growth factor (NGF), to accelerate corneal epithelial cell migration and proliferation during healing and regeneration.18-27 Disruption of corneal innervation can cause degenerative conditions ranging from dry eye to neurotrophic keratitis.28 The symptoms accelerate cell loss leading to corneal epithelial thinning, increased epithelial permeability, and wound healing deficiency. Most neurotrophic keratitis results from herpetic viral infection; however, ocular surgery such as laser-assisted in situ keratomileusis (LASIK) and corneal transplants, even the use of contact lenses, can lead to damage of corneal nerves.28-31 We hypothesized that corneal epithelial degeneration in PAX6+/− humans and mice may be in part a type of neurotrophic keratitis. |
| Databáze: | OpenAIRE |
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