Essential thrombocythaemia as a causative agent of portal vein thrombosis: A case report
| Autor: | Mirko Kerkez, Djordje Culafic, Violeta Culafic-Vojinovic, Predrag Miljic, Dejan Stefanovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class lcsh:Medicine essential thrombocythaemia Esophageal and Gastric Varices Gastroenterology Myeloproliferative Disorders Internal medicine medicine Humans portal vein thrombosis Venous Thrombosis Thrombocytosis treatment business.industry Portal Vein Anticoagulant lcsh:R General Medicine Middle Aged medicine.disease Thrombosis Discontinuation Portal vein thrombosis Surgery Panendoscopy business Varices Gastrointestinal Hemorrhage Thrombocythemia Essential |
| Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 137, Iss 1-2, Pp 77-80 (2009) |
| ISSN: | 0370-8179 |
| Popis: | Introduction. Thrombosis of splanchnic blood vessels is one of the most difficult complications and most frequent causes of death in patients with myeloproliferative disorders. Case Outline. We report a 48-year-old man with recurring haemorrhage from the upper digestive tract. Doppler ultrasonography of the portal system revealed a thrombosed portal vein, with marginal flow of 10 cm/s. Peroral fiber panendoscopy of the oesophagus showed III-IV degree varices together with varices in the stomach fundus. Blood count revealed thrombocytosis (Pt. 900 x 109/l), and haematological analysis led to the diagnosis of essential thrombocythaemia. However, two years after the established diagnosis, the patient was hospitalized again for bleeding from esophageal varicosity. During haemorrhage, anticoagulant therapy was discontinued. Eight days after anticoagulant discontinuation, mesenterial thrombosis and small intestinal gangrene developed. Surgical intervention was carried out, including resection of 2.5 m of the small intestine. In spite of intensive postoperative therapy, the lethal outcome ensued. Conclusion. The bleeding from oesophageal and/or gastric varicosity is often the presenting manifestation of up to that time undetected myeloproliferative disease. The following question still remains open: should anticoagulant therapy be continued in the phase of acute bleeding of these patients?. |
| Databáze: | OpenAIRE |
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