Mild splenic sequestration crises in sickle-hemoglobin C disease
| Autor: | George R. Buchanan, Joann Andrews |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Anemia Disease Anemia Sickle Cell Gastroenterology 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine medicine Splenic sequestration Humans Hemoglobin SC Disease business.industry medicine.disease Sickle cell anemia Red blood cell medicine.anatomical_structure Epistaxis Shock (circulatory) Pediatrics Perinatology and Child Health Immunology Acute Disease Splenomegaly medicine.symptom Complication business |
| Zdroj: | Clinical pediatrics. 23(6) |
| ISSN: | 0009-9228 |
| Popis: | Acute splenic sequestration crisis (ASSC), a common complication in homozygous sickle cell anemia, has been described infrequently in sickle-hemoglobin C (SC) disease in the absence of high altitude exposure. In this report, we describe three children with hemoglobin SC disease who developed episodes of ASSC that were milder than those generally described in sickle cell anemia. In one patient, an antecedent triggering event was not recognized. The other two children may have had a predisposing cause for massive intrasplenic sickling in that one had an associated mononucleosis syndrome and the other an episode of hypovolemic shock following severe epistaxis. ASSC may occur in patients with SC disease and does not necessarily require a hypoxic trigger associated with high altitudes. |
| Databáze: | OpenAIRE |
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