Co-occurrence of pain and dyspnea in Veterans with COPD: Relationship to functional status and a pilot study of neural correlates using structural and functional magnetic resonance imaging
Autor: | Rebekah L. Goldstein, David H. Salat, Maria A. Mongiardo, Rinu A. Daniel, Marilyn L. Moy, Diana M. Higgins, Paola N. Cruz Rivera |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Pulmonology
Physiology Pilot Projects Walking Diagnostic Radiology Medical Conditions 0302 clinical medicine Medicine and Health Sciences Medicine Public and Occupational Health Veterans COPD Multidisciplinary medicine.diagnostic_test Radiology and Imaging Middle Aged Magnetic Resonance Imaging Research Design Analysis of variance Research Article medicine.medical_specialty Imaging Techniques Chronic Obstructive Pulmonary Disease Science Pain Walk Test Neuroimaging Research and Analysis Methods Respiratory Disorders 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Humans Exercise Aged Neural correlates of consciousness Resting state fMRI Biological Locomotion business.industry Biology and Life Sciences Pilot Studies Magnetic resonance imaging Physical Activity medicine.disease Dyspnea 030228 respiratory system Pedometer Physical therapy Clinical Medicine business Functional magnetic resonance imaging 030217 neurology & neurosurgery Neuroscience |
Zdroj: | PLoS ONE, Vol 16, Iss 7, p e0254653 (2021) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Persons with COPD experience co-occurring dyspnea and pain. Little is known about the relationship between symptom co-occurrence with physical activity (PA) and exercise. Novel diagnostic tools are needed for accurate symptom discrimination. In this secondary analysis, we examined relationships between baseline assessments of pain, dyspnea, objectively measured PA, and exercise capacity in persons with COPD who previously enrolled in three PA studies. Pain was assessed with the bodily pain domain of the Veterans RAND-36 (VR-36), and dyspnea with the modified Medical Research Council (mMRC) scale. Average daily step count was assessed with the Omron HJ-720ITC or FitBit Zip pedometer, and exercise capacity with 6-minute walk test (6MWT). We also conducted a pilot neuroimaging study. Neuroimaging data were acquired on a Siemens 3-Tesla Magnetom Prismafit whole-body scanner. Analysis of variance assessed trends in daily step count and 6MWT distance across categories of co-occurring pain and dyspnea. General linear models examined relationships between cortical thickness and resting state functional connectivity (fc) with symptoms and functional status. In 373 Veterans, 98% were male with mean age 70.5± 8.3 years and FEV1% predicted 59 ± 21%. Compared to those with no co-occurrence of pain and dyspnea, those with co-occurrence walked 1,291–1,444 fewer steps per day and had an 80–85 m lower 6MWT distance. Ten males participated in the pilot neuroimaging study. Predominant findings were that lower cortical thickness and greater fc were associated with higher pain and dyspnea, p |
Databáze: | OpenAIRE |
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