Co-occurrence of pain and dyspnea in Veterans with COPD: Relationship to functional status and a pilot study of neural correlates using structural and functional magnetic resonance imaging

Autor: Rebekah L. Goldstein, David H. Salat, Maria A. Mongiardo, Rinu A. Daniel, Marilyn L. Moy, Diana M. Higgins, Paola N. Cruz Rivera
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pulmonology
Physiology
Pilot Projects
Walking
Diagnostic Radiology
Medical Conditions
0302 clinical medicine
Medicine and Health Sciences
Medicine
Public and Occupational Health
Veterans
COPD
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Middle Aged
Magnetic Resonance Imaging
Research Design
Analysis of variance
Research Article
medicine.medical_specialty
Imaging Techniques
Chronic Obstructive Pulmonary Disease
Science
Pain
Walk Test
Neuroimaging
Research and Analysis Methods
Respiratory Disorders
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Humans
Exercise
Aged
Neural correlates of consciousness
Resting state fMRI
Biological Locomotion
business.industry
Biology and Life Sciences
Pilot Studies
Magnetic resonance imaging
Physical Activity
medicine.disease
Dyspnea
030228 respiratory system
Pedometer
Physical therapy
Clinical Medicine
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 16, Iss 7, p e0254653 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Persons with COPD experience co-occurring dyspnea and pain. Little is known about the relationship between symptom co-occurrence with physical activity (PA) and exercise. Novel diagnostic tools are needed for accurate symptom discrimination. In this secondary analysis, we examined relationships between baseline assessments of pain, dyspnea, objectively measured PA, and exercise capacity in persons with COPD who previously enrolled in three PA studies. Pain was assessed with the bodily pain domain of the Veterans RAND-36 (VR-36), and dyspnea with the modified Medical Research Council (mMRC) scale. Average daily step count was assessed with the Omron HJ-720ITC or FitBit Zip pedometer, and exercise capacity with 6-minute walk test (6MWT). We also conducted a pilot neuroimaging study. Neuroimaging data were acquired on a Siemens 3-Tesla Magnetom Prismafit whole-body scanner. Analysis of variance assessed trends in daily step count and 6MWT distance across categories of co-occurring pain and dyspnea. General linear models examined relationships between cortical thickness and resting state functional connectivity (fc) with symptoms and functional status. In 373 Veterans, 98% were male with mean age 70.5± 8.3 years and FEV1% predicted 59 ± 21%. Compared to those with no co-occurrence of pain and dyspnea, those with co-occurrence walked 1,291–1,444 fewer steps per day and had an 80–85 m lower 6MWT distance. Ten males participated in the pilot neuroimaging study. Predominant findings were that lower cortical thickness and greater fc were associated with higher pain and dyspnea, p
Databáze: OpenAIRE
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