Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

Autor: Samantha Fraser-Bell, Liga Radecka, Matias Iglicki, Adrian T. Fung, Voraporn Chaikitmongkol, Małgorzata Ozimek, Matus Rehak, Anna Sala-Puigdollers, Anat Loewenstein, Catharina Busch, Shai Cohen, Aude Couturier, Tiago Rodrigues, Atchara Amphornphruet, Pierre-Henry Gabrielle, Inês Laíns, Zafer Cebeci, Mali Okada, Dinah Zur, Miriana Mariussi, Marco Lupidi, Danilo Iannetta
Přispěvatelé: Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Leipzig University, National University of Central Buenos Aires, Royal Victorian Eye and Ear Hospital, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université Bourgogne Franche-Comté [COMUE] (UBFC), Tel Aviv University [Tel Aviv], Favaloro University, Partenaires INRAE, Rajavithi Hospital, Istanbul University, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Sydney, Macquarie University, Westmead Hospital [Sydney], Royal Liverpool University Hospital, S. Eugenio Hospital, Tor Vergata University, Pauls Stradins Clinical University Hospital, Universidade de Coimbra, Harvard Medical School [Boston] (HMS), Università degli Studi di Perugia (UNIPG), Medical University in Lublin, Hospital Clínic de Barcelona, Tel-Aviv Sourasky Medical Center
Rok vydání: 2018
Předmět:
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
medicine.drug_class
Endophthalmitis
Intravitreal injection
Vascular endothelial growth factor
Antibiotics
Visual Acuity
01 natural sciences
Eye Infections
Bacterial
03 medical and health sciences
0302 clinical medicine
Endophthalmitis
Retinal Diseases
Internal medicine
Antibiotic therapy
Medicine
Humans
ddc:610
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
0101 mathematics
Aged
Retrospective Studies
Anti vegf
vascular endothelial growth factor
biology
Injection Procedure
Bacteria
business.industry
010102 general mathematics
intravitreal injection
General Medicine
biology.organism_classification
medicine.disease
Sensory Systems
3. Good health
Anti-Bacterial Agents
Vitreous Body
Ophthalmology
Multicenter study
Viridans streptococci
Baseline characteristics
Intravitreal Injections
030221 ophthalmology & optometry
Female
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Follow-Up Studies
Zdroj: Ophthalmologica
Ophthalmologica, Karger, 2019, 241 (4), pp.211-219. ⟨10.1159/000496942⟩
ISSN: 1423-0267
0030-3755
DOI: 10.1159/000496942⟩
Popis: Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.
Databáze: OpenAIRE
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