Serum and salivary antigliadin antibodies and serum IgA anti-endomysium antibodies as a screening test for coeliac disease
| Autor: | J. Rujner, E Barra, Woźniewicz B, Gregorek H, B Giera, K. Madalinski, Jerzy Socha |
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| Rok vydání: | 1996 |
| Předmět: |
Immunoglobulin A
Saliva Adolescent Autoimmunity Immunofluorescence Sensitivity and Specificity Coeliac disease Gliadin Intestinal mucosa Blood plasma medicine Humans Mass Screening Serologic Tests Child medicine.diagnostic_test biology business.industry General Medicine medicine.disease Endomysium Celiac Disease medicine.anatomical_structure Child Preschool Immunoglobulin G Pediatrics Perinatology and Child Health Immunology Immunoglobulin A Secretory biology.protein Antibody business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 85(7) |
| ISSN: | 0803-5253 |
| Popis: | Serum and salivary IgA and IgG antigliadin antibodies were determined by an enzyme-linked immunosorbent assay in 18 children with villous atrophy and 30 children on a gluten-free diet for coeliac disease in whom normal intestinal mucosa was found. Serum IgA anti-endomysium antibodies were also determined by an immunofluorescence method in these children. Serum IgG antigliadin and IgA anti-endomysium antibodies had the highest sensitivity (100 and 94.4%, respectively), followed by serum IgA antibodies to gliadin (72.2%), salivary IgA antigliadin (61.2%) and IgG antigliadin (50%) antibodies. The highest specificity was found for serum IgA anti-endomysium (100%) and IgA antigliadin (96.6%) antibodies and salivary IgA and IgG antigliadin antibodies (93.3%), while serum IgG antigliadin antibodies were found to be least specific (63.3%). |
| Databáze: | OpenAIRE |
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