Obstetric outcomes of human herpes virus-2 infection among pregnant women in Benin, Nigeria
| Autor: | Victor Ugochukwu Nwadike, Eziyi Iche Kalu, A Chuku, F C Korie, G O C Okafor, F E Agwu, Chiedozie Kingsley Ojide, I I Chukwuonye |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Adolescent viruses Herpesvirus 2 Human Population Nigeria Abortion Antibodies Viral Young Adult Pregnancy medicine Humans Prospective Studies Pregnancy Complications Infectious Prospective cohort study education reproductive and urinary physiology First episode education.field_of_study Herpes Genitalis business.industry Infant Newborn Pregnancy Outcome General Medicine Middle Aged medicine.disease Delivery Obstetric Low birth weight Relative risk Female medicine.symptom business Blood sampling |
| Zdroj: | Nigerian journal of clinical practice. 18(4) |
| ISSN: | 1119-3077 |
| Popis: | Objective: This study investigated the obstetric outcomes of herpes simplex virus (HSV-2) infection among pregnant women. Materials and Methods: In this prospective cohort study, a total of 674 consenting pregnant women attending ante-natal clinic in the University of Benin Teaching Hospital and Central Hospital Benin were recruited between November 2011 and December, 2012. The women were screened for HSV-1, and HSV-2 using glycoprotein-G-based type-specific Enzyme Linked Immunosorbent Assay on archived blood samples; and were followed up to the delivery period and postnatal clinic. The HSV-2-seronegative participants underwent second blood sampling for HSV-2 IgG and IgM assay during the delivery period. The patients were thus categorized into HSV-2 seropositive, HSV-2-seronegative, and incident HSV-2 infection cohorts. The pregnancy outcomes were assessed by review of hospital records. Data analysis was with SPSS version 16 software. Results: Of 674 pregnant women surveyed, 312 (46.3%) were HSV-2 seropositive; while 362 (56.7%) were HSV-2 seronegative. Comparing the HSV-2 seropositive and HSV-seronegative groups, there were no significant differences in occurrence of low birth weight (LBW), prematurity, spontaneous abortions, and stillbirth events (P = 0.96; 0.95; 1.0; and 0.77, respectively). Comparing the incident HSV-2 infection with the HSV-2 seronegative groups, the relative risks of occurrence of LBW deliveries, preterm deliveries, and stillbirths were 12.6, 25.1, and 4.5, respectively. Conclusion: First episode HSV-2 infection among pregnant women in Benin, Nigeria is associated with an increased risk of occurrence of spontaneous abortion, LBW delivery, stillbirths, and preterm delivery. |
| Databáze: | OpenAIRE |
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