Role of the extracellular matrix in variations of invasive pathways in lung cancers

Autor: V. K. de Sá, Vitor Sousa, Ana Alarcão, Vera Luiza Capelozzi, Maria Reis Silva, Lina Carvalho, Fernando Augusto Soares, Patrícia Couceiro, Ana Gomes
Rok vydání: 2012
Předmět:
Male
Pathology
Lung Neoplasms
Physiology
Hyal-1 and Hyal-3
Biochemistry
Extracellular matrix
General Pharmacology
Toxicology and Pharmaceutics
Glucuronosyltransferase
lcsh:QH301-705.5
Aged
80 and over
lcsh:R5-920
Cell adhesion molecule
General Neuroscience
General Medicine
Middle Aged
Cadherins
Immunohistochemistry
Extracellular Matrix
Carcinoma
Squamous Cell
Female
Lung cancer
lcsh:Medicine (General)
Adult
TGF-β
medicine.medical_specialty
Stromal cell
Immunology
Biophysics
Ocean Engineering
Adenocarcinoma of Lung
Biology
Adenocarcinoma
Stroma
Carcinoma
medicine
Humans
Prognosis and morphometry
Neoplasm Invasiveness
TGF
Aged
Neoplasm Staging
Cadherin
Biomedical Sciences
E-cadherin
Cell Biology
medicine.disease
lcsh:Biology (General)
HAS-1
HAS-2 and HAS-3
Cell Adhesion Molecules
Hyaluronan Synthases
Zdroj: Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research, Volume: 46, Issue: 1, Pages: 21-31, Published: 11 JAN 2013
Brazilian Journal of Medical and Biological Research, Vol 46, Iss 1, Pp 21-31 (2013)
Brazilian Journal of Medical and Biological Research v.46 n.1 2013
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
ISSN: 1414-431X
Popis: Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix. The remarkable qualitative and quantitative modifications of hyaluronidases (HAases), hyaluronan synthases (HAS), E-cadherin adhesion molecules, and the transforming growth factor β (TGF-β) may favor invasion, cellular motility, and proliferation. We examined HAase proteins (Hyal), HAS, E-cadherin, and TGF-β profiles in lung AD subtypes and SqCC obtained from smokers and non-smokers. Fifty-six patients, median age 64 years, who underwent lobectomy for AD (N = 31) and SqCC (N = 25) were included in the study. HAS-1, -2 and -3, and Hyal-1 and -3 were significantly more expressed by tumor cells than normal and stroma cells (P < 0.01). When stratified according to histologic types, HAS-3 and Hyal-1 immunoreactivity was significantly increased in tumor cells of AD (P = 0.01) and stroma of SqCC (P = 0.002), respectively. Tobacco history in patients with AD was significantly associated with increased HAS-3 immunoreactivity in tumor cells (P < 0.01). Stroma cells of SqCC from non-smokers presented a significant association with HAS-3 (P < 0.01). Hyal, HAS, E-cadherin, and TGF-β modulate a different tumor-induced invasive pathway in lung AD subgroups and SqCC. HAases in resected AD and SqCC were strongly related to the prognosis. Therefore, our findings suggest that strategies aimed at preventing high HAS-3 and Hyal-1 synthesis, or local responses to low TGF-β and E-cadherin, may have a greater impact in lung cancer prognosis.
Databáze: OpenAIRE
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