Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset
| Autor: | Deepti M. Reddi, Tengda Lin, Yosef Nasseri, Laura A. Lambert, Biljana Gigic, Robert W. Decker, Eiman Firoozmand, Mukta K. Krane, Cornelia M. Ulrich, Bartley Pickron, William M. Grady, Erin M. Siegel, Alessandro Fichera, Sheetal Hardikar, Nathan M. Hinkle, Mary P. Bronner, Zuri Murrell, David M. J. Hoffman, Beth A. Moore, Jennifer Ose, Adetunji T. Toriola, Mika Sinanan, Matthew G. Mutch, Anita R. Peoples, Cory T. Bernadt, Eric A. Swanson, Ravi Moonka, Jessica N. Cohan, Johanna Nattenmueller, Jolanta Jedrzkiewicz, Jane C. Figueiredo, Ulrike Wallin, Andrew Eugene Hendifar, Christopher I. Li, Lyen C. Huang, Magnus von Knebel-Doeberitz, Julian Sanchez, Justin J. Monroe, Maryliza S. El-Masry, Stephanie L. Schmit, Kyle G. Cologne, Alexandra Gangi, Domenico Coppola, Peter Schirmacher, David Shibata, Deyali Chatterjee, Karen Zaghiyan, Seth Felder, Courtney L. Scaife, Sophie Dessureault, Paul D. Lampe, Matthias Kloor, Esther Herpel, Hans-Ulrich Kauczor, Stacey A. Cohen, Caroline Himbert, Jun Gong, Alexis Ulrich |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Colorectal cancer Oncology and Carcinogenesis early onset colorectal cancer Disease Overweight Article 03 medical and health sciences 0302 clinical medicine Clinical Research Internal medicine Epidemiology medicine RC254-282 Cancer business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Odds ratio cohort medicine.disease Confidence interval Colo-Rectal Cancer Oncology 030220 oncology & carcinogenesis Cohort 030211 gastroenterology & hepatology epidemiology Age of onset medicine.symptom business Digestive Diseases |
| Zdroj: | Cancers, vol 13, iss 15 Cancers Cancers, Vol 13, Iss 3817, p 3817 (2021) Volume 13 Issue 15 |
| Popis: | Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (< 50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patients (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors with age of onset using mutually-adjusted logistic regression models. Patients were on average 60 years old, with BMI of 29 kg/m2, 52% colon cancers, 21% early-onset, and presented with stage II or III (60%) disease. Early-onset patients presented with more advanced disease (stages III–IV: 63% vs. 51%, respectively), and received more neo and adjuvant treatment compared to late-onset patients, after controlling for stage (odds ratio (OR) (95% confidence interval (CI)) = 2.30 (1.82–3.83) and 2.00 (1.43–2.81), respectively). Early-onset rectal cancer patients across all stages more commonly received neoadjuvant treatment, even when not indicated as the standard of care, e.g., during stage I disease. The odds of early-onset disease were higher among never smokers and lower among overweight patients (1.55 (1.21–1.98) and 0.56 (0.41–0.76), respectively). Patients with early-onset colorectal cancer were more likely to be diagnosed with advanced stage disease, to have received systemic treatments regardless of stage at diagnosis, and were less likely to be ever smokers or overweight. |
| Databáze: | OpenAIRE |
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