Outcomes of COVID-19 in Hematopoietic Stem Cell Transplant Recipients: Multicenter Retrospective Analysis

Autor: Narendra Agrawal, Vipin Khandelwal, Sanjeev Sharma, Divya Doval, Rahul Naithani, Preethi Jeyaraman, Nitin Bansal, Rayaz Ahmed, Rahul Bhargava, Dharma Choudhary, Sachin Bansal, Dinesh Bhurani, Reema Singh
Rok vydání: 2021
Předmět:
Zdroj: Indian Journal of Hematology & Blood Transfusion
ISSN: 0974-0449
0971-4502
Popis: COVID-19, caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), was declared a pandemic by the World Health Organization on March 9, 2020. Hematopoietic stem-cell transplantation (HSCT) recipients may be highly susceptible to infection and related pulmonary complications due to nascent immune systems or organ damage from treatment-related toxicities. Poor outcomes in such group of patients were linked to older age, steroid therapy at the time of COVID-19 infection, and COVID-19 infection within a year of HSCT. We studied a cohort of 28 hematopoietic stem cell transplant recipients (male 17, M:F ratio of 1.5) with COVID-19 infection from 1st June 2020, through 31st December 2020 for outcome. Fever was the most common symptom at the time of presentation in 22 (78.5%) patients. Mortality rate at Day 28 and Day 42 was found to be 4/28 (14.3%) and 7/28 (25%) respectively. Patients within one year of HSCT and severe infection had higher day 28 mortality (with p values = 0.038)". There was no relation of mortality with type of transplant.
Databáze: OpenAIRE
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