Primary auditory cortex regulates threat memory specificity
| Autor: | Mattis B. Wigestrand, Hillary C. Schiff, Marianne Fyhn, Joseph E. LeDoux, Robert M. Sears |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Auditory perception Stimulus generalization Cognitive Neuroscience Conditioning Classical Stimulus (physiology) Brief Communication Auditory cortex 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Discrimination Psychological 0302 clinical medicine Memory medicine Animals GABA-A Receptor Agonists Enzyme Inhibitors Protein Kinase C Auditory Cortex Analysis of Variance Muscimol Fear Rats 030104 developmental biology Neuropsychology and Physiological Psychology chemistry Anxiety Memory acquisition medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Learning & Memory. 24:55-58 |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.044362.116 |
| Popis: | Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKMζ inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|