Study of the effect of the chromophore and nuclearity on the aggregation and potential biological activity of gold(I) alkynyl complexes
| Autor: | Ingo Ott, Jordi Llorca, Julia Schur, Elisabet Aguiló, Laura Rodríguez, Raquel Gavara |
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| Přispěvatelé: | Universitat de Barcelona, Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya. NEMEN - Nanoenginyeria de materials aplicats a l'energia |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Luminescence
Thioredoxin reductase Cytotoxicity Enginyeria química::Química inorgànica [Àrees temàtiques de la UPC] Or Organometallic compounds Ciències de la salut::Medicina::Medicina interna [Àrees temàtiques de la UPC] 010402 general chemistry Photochemistry 01 natural sciences Inorganic Chemistry Metal Alkynyl chemistry.chemical_compound In-vitro Carbene complexes Materials Chemistry Mechanisms Emission spectrum Compostos organometàl·lics Physical and Theoretical Chemistry TPPTS Inhibition Farmacologia molecular 010405 organic chemistry Drugs Chromophore 0104 chemical sciences Ciències de la salut::Medicina::Farmacologia [Àrees temàtiques de la UPC] Intersystem crossing chemistry visual_art visual_art.visual_art_medium Antitumor-activity derivatives Gold Absorption (chemistry) Phosphorescence Molecular pharmacology |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | The synthesis and characterization of four organometallic gold(I) complexes containing different water soluble phosphanes (TPPTS, PTA and DAPTA) and chromophoric units (4-pyridylethynyl and propargyloxycoumarin) is here reported. The analysis of their absorption and emission spectra led us to attribute their luminescent behavior to the chromophoric organic ligands. Moreover, the presence of the gold(I) metal atom has been observed to be the responsible of an efficient intersystem crossing process responsible for the observed phosphorescence emission. Broad emission bands are observed in most cases due to the formation of organized aggregates in solution in agreement with microscopic characterization. Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR). The missing/low cytotoxic effects could be related to a low bioavailability as determined by atomic absorption spectroscopy. Graphical abstract The synthesis, characterization, aggregation and emissive properties of four organometallic gold(I) complexes containing different water soluble phosphanes and chromophoric units is here reported. Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR) |
| Databáze: | OpenAIRE |
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