Comparative study of perturbations of peripheral markers in different stressors in rats
| Autor: | Gitika Bhatia, Tuhinadri Sen, Gautam Palit, Deepak Rai |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Peptic Ulcer medicine.medical_specialty Physiology medicine.medical_treatment Ulcer index Rats Sprague-Dawley Immobilization chemistry.chemical_compound Stress Physiological Corticosterone Physiology (medical) Internal medicine Adrenal Glands medicine Animals Insulin Creatine Kinase Triglycerides Pharmacology biology Triglyceride Adrenal gland business.industry Stomach Hypertrophy General Medicine Adaptation Physiological Rats Cholesterol medicine.anatomical_structure Endocrinology chemistry biology.protein Creatine kinase Energy Metabolism business Biomarkers Glucocorticoid Hormone medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 81:1139-1146 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | Stress has been implicated in the etiopathogenesis of several diseases. In the present study, the effects of acute (AS), chronic (CS), and chronic unpredictable stress (CUS) were studied on the ulcer index, adrenal gland mass, and biochemical and hormonal changes in rats. The stress was provided in the form of immobilization — immobilization for 150 min, once only, and for 10 consecutive days in CS and CUS. In CUS, animals received variable unpredictable stressors. Immediately after stress, animals were decapitated, blood was collected, and plasma was separated for the esti ma tion of plasma glucose, triglyceride, cholesterol, creatine kinase (CK), corticosterone, and insulin. The adrenal gland and stomach were also dissected for mass and ulcer scoring, respectively. AS significantly increased the ulcer index, plasma glucose, CK, corticosterone, and insulin. CS and CUS significantly increased the ulcer index, adrenal gland mass, and corticosterone. In CS, a significant decrease in plasma triglyceride and cholesterol levels was found, but in CUS only cholesterol was decreased significantly. High CK activity and hyperglycemia maintain the energy demands of metabolism, and elevated corticosterone desensitizes the insulin receptor in AS. In CS and CUS, prolonged elevation of corticosterone shifts metabolism to utilization of lipids as a secondary substrate by gluconeogenesis. From our experiment, it is clear that AS causes maximum activation of energy metabolism, which becomes specific after habituation in prolonged CS. These biochemical manipulations in the body by using different types of stressors are good markers that can be of great use to understand, target, and manage stress-induced etiologies.Key words: stress, adrenal hypertrophy, hormones, glucose, lipids, creatine kinase. |
| Databáze: | OpenAIRE |
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