Cardiovascular autonomic reactivity is decreased in adolescents with Type 1 diabetes
| Autor: | Kalervo Suominen, Päivi H. Riihimaa, Uolevi Tolonen, Mikael Knip, Päivi Tapanainen |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Supine position Adolescent Endocrinology Diabetes and Metabolism Posture Diaphragmatic breathing Blood Pressure 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetic Neuropathies Heart Rate Internal medicine Heart rate Reaction Time Internal Medicine medicine Humans Heart rate variability Child Type 1 diabetes business.industry Puberty medicine.disease Autonomic nervous system Cross-Sectional Studies Diabetes Mellitus Type 1 Blood pressure Cardiology Female business Polyneuropathy |
| Zdroj: | Diabetic Medicine. 19:932-938 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1046/j.1464-5491.2002.00816.x |
| Popis: | Aims To characterize autonomic nervous system function by means ofthe heart rate and blood pressure responses to various stimuli in relationto pubertal maturation in patients with Type 1 diabetes mellitus (DM). Methods One hundred out of 138 eligible patients at the Out-patient Diabetes Clinicand 100 healthy control subjects were examined in terms of cardiovascularparameters at rest, during deep breathing and when standing. Heartrate variabil-ity was analysed with time domain,frequency domain and fractal dimension parameters. Tanner pubertalstaging was performed before the examinations. Results The time domain parameters of heart rate variability at restor during standing did not significantly differ between the patientsand controls in total or at pubertal stages. In the spectral analysis ofheart rate variability the very low frequency band was decreasedin the patients during standing (P = 0.023).The increase in the very low frequency (P = 0.013)and low frequency (P = 0.031) spectralpowers upon changing from a supine position to standing was attenuatedin the patients in total, while no significant differences wereobserved within the Tanner pubertal stages between patients and controls.Heart rate variability during deep breathing was decreased in the patientswith distal polyneuropathy (P = 0.006). Conclusions Although cardiovascular integrity is in the main well preserved inadolescent patients with Type 1 DM, these patients are prone toattenuated autonomic nervous system reactivity. Diabet. Med. 19, 932–938 (2002) |
| Databáze: | OpenAIRE |
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