Antibiotics in Dentoalveolar Surgery, a Closer Look at Infection, Alveolar Osteitis and Adverse Drug Reaction
Autor: | Simra Azher, Amish Patel |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions Osteoradionecrosis medicine.medical_treatment Dry Socket Context (language use) 03 medical and health sciences 0302 clinical medicine medicine Humans Dental implant Intensive care medicine Adverse effect business.industry Amoxicillin 030206 dentistry Antibiotic Prophylaxis medicine.disease Anti-Bacterial Agents Otorhinolaryngology 030220 oncology & carcinogenesis Infective endocarditis Surgery Oral Surgery Osteitis business Osteonecrosis of the jaw Adverse drug reaction |
Zdroj: | Journal of Oral and Maxillofacial Surgery. 79:2203-2214 |
ISSN: | 0278-2391 |
Popis: | Purpose To execute an evidence-based review answering the following questions: “What antibiotic type and mode of delivery are most effective at reducing inflammatory complications in third molar and dental implant surgery? What are the types and rates of antibiotic-related adverse reactions in the context of third molar surgery, infective endocarditis, medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN)?” Material and Methods We performed a comprehensive literature review of peer-reviewed studies using MEDLINE/PubMed, Cochrane, Scopus/Elsevier, Google Scholar, and Wiley online library databases. Results Twenty-five studies were reviewed for third molar surgery. Although there is some evidence that systemic antibiotics reduce inflammatory complications (infection and alveolar osteitis), routine use is not recommended for third molar surgery. For at-risk cases, a single preoperative dose of amoxicillin is preferred. Clindamycin, amoxicillin-clavulanic acid and erythromycin have a high adverse risk profile. Eight studies were reviewed for dental implant surgery. Antibiotics with dental implant placement showed little reduction in post surgery infection and minimal improvement in long-term success. A comprehensive search found limited data on antibiotic-related adverse effects in the context of infective endocarditis, MRONJ and ORN. Conclusions A set of clinical recommendations are presented to better guide evidence-based and standardized antibiotic usage on the basis of the literature discussed in this review. This review highlights the need for further research focusing on antibiotic type and timing of delivery with adverse drug reaction as a primary outcome measure when assessing treatment outcomes and complications in dentoalveolar surgery. This will better elucidate the risks vs benefits of antibiotic in dentoalveolar surgery. |
Databáze: | OpenAIRE |
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