The inactivating and mutagenic effect of hydroxylamine on bacteriophage phi x-174
| Autor: | G.A. van Arkel, J.H. van de Pol |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Nitrous acid
biology Chemical Phenomena Health Toxicology and Mutagenesis Kinetics Nucleosides biology.organism_classification Hydroxylamines Coliphages Bacteriophage chemistry.chemical_compound Chemistry Hydroxylamine chemistry Biochemistry DNA Viral Mutation Genetics Ultraviolet irradiation Cysteine Biologie Molecular Biology Nuclear chemistry Mutagens |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2(5), 466. Elsevier |
| ISSN: | 0027-5107 |
| Popis: | The inactivation of bacteriophage ΦXI74 by the mutagenic agents nitrous acid and ultraviolet irradiation proceeds according to a single-hit kinetics. However, treatment of purified ΦXI74 by hydroxylamine (HA) at pH 6 and 25° results in an inactivation that is not strictly exponential. The inactivation curves contain a shoulder, which is easily detectable at a HA concentration of o.1 M. The ultimate slope of the curves at this concentration is in many cases greater than at 1 M. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|