Effects of Acute Salbutamol Intake on Peripheral and Central Fatigue in Trained Men
| Autor: | Mathieu Marillier, Julien Laurent, Michel Guinot, Julie Larribaut, Thibault Le Roux Mallouf, Samuel Verges |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_treatment Prefrontal Cortex Physical Therapy Sports Therapy and Rehabilitation Performance-Enhancing Substances Isometric exercise Placebo Quadriceps Muscle Young Adult 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Double-Blind Method parasitic diseases medicine Humans Albuterol Orthopedics and Sports Medicine Exercise Cross-Over Studies Spectroscopy Near-Infrared Electromyography business.industry 030229 sport sciences Oxygenation Transcranial Magnetic Stimulation Peripheral Stimulant Transcranial magnetic stimulation Oxyhemoglobins Anesthesia Muscle Fatigue Physical Endurance Salbutamol Hemoglobin business 030217 neurology & neurosurgery Muscle Contraction medicine.drug |
| Zdroj: | Medicine & Science in Sports & Exercise. 50:1267-1276 |
| ISSN: | 1530-0315 0195-9131 |
| DOI: | 10.1249/mss.0000000000001565 |
| Popis: | PURPOSE Ergogenic effect in physically active subjects has been reported after acute salbutamol (SAL) intake. β2-Agonists have potential stimulant effects within the central nervous system that could be involved in this ergogenic effect. We hypothesized that acute SAL intake would induce changes in cerebral responses during exercise, with significant improvement in cerebral oxygenation and voluntary activation (VA) contributing to an increase in muscle performance. METHODS Fourteen trained male subjects (25 ± 5 yr) performed repeated isometric knee extensions until task failure (TF) after 4 mg (oral) SAL, 800 μg (inhaled) SAL, or placebo intake. VA, corticospinal excitability, and inhibition assessed by transcranial magnetic stimulation and changes in hemoglobin concentrations assessed by near-infrared spectroscopy were measured before and during the fatiguing task. RESULTS SAL had no significant effect both at rest and during exercise on prefrontal cortex oxygenation (e.g., changes in oxyhemoglobin concentration at TF: 11.4 ± 11.1 (4 mg SAL) vs 10.4 ± 10.6 (800 μg SAL) vs 10.8 ± 8.1 μmol (placebo); P = 0.314) and neuromuscular function (e.g., VA measured by TMS at TF: 90.2% ± 6.6% vs 92.6% ± 5.0% vs 90.1% ± 7.0%; P = 0.760). SAL had no effect on the number of contractions until TF (95 ± 51 vs 100 ± 52 vs 93 ± 47; P = 0.629). CONCLUSIONS These results indicate that acute SAL intake had no effect on central and peripheral mechanisms of neuromuscular fatigue and did not improve quadriceps endurance. |
| Databáze: | OpenAIRE |
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