Pathological and immunohistochemical study of colon cancer. Evaluation of markers for colon cancer stem cells
| Autor: | Konstantinos Sapalidis, Stelian Ştefăniţă Mogoantă, Adrian Murea, Tiberiu Ştefăniţă Ţenea-Cojan, Daniel Sorin Ilie, Bogdan Dan Totolici, Carmen Neamţu, I Păun, George Mitroi |
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| Rok vydání: | 2021 |
| Předmět: |
cancer stem cells
Embryology Colorectal cancer Pathology and Forensic Medicine Cancer stem cell Medicine Humans Original Paper adenocarcinoma biology Cluster of differentiation business.industry CD24 CD44 Cell Biology General Medicine medicine.disease ALDH1A1 Pleomorphism (cytology) colon cancer Colonic Neoplasms mucinous carcinoma immunohistochemistry biology.protein Cancer research Neoplastic Stem Cells Stem cell business Colorectal Neoplasms Developmental Biology |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 |
| Popis: | Colorectal cancer is a major public health problem worldwide with increasing morbidity and mortality. Numerous exogenous and endogenous factors are involved in colorectal carcinogenesis: age, sex, diet, smoking, alcohol consumption, exposure to harmful environmental factors, intestinal microbiota, bacterial and viral infections, the ability of the host immune system to respond, genetic factors, etc. The present study analyzed histopathologically and immunohistochemically a number of 36 cases of colorectal adenocarcinomas. The existence of an accentuated cell pleomorphism was noted, which corresponds to different clones of tumor cells, in the same tumor coexisting aspects of tubular adenocarcinoma, mucinous areas and even signet-ring cell. The tumor stroma was mainly of the desmoplastic type, but also of the lax type, more or less infiltrated with inflammatory cells. Evaluation of immunomarkers for cancer stem cells (CSCs) showed that none of the markers used alone [cluster of differentiation (CD)133, CD44, aldehyde dehydrogenase 1 family member A1 (ALDH1A1), CD24, CD26] show CSCs. |
| Databáze: | OpenAIRE |
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