Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases
| Autor: | Chihaya Koriyama, Satoshi Ota, Yuji Ohtsuki, Yueh-Min Lin, Kun-Yong Kwon, Min En Nga, Suminori Akiba, Chul Woo Kim, Akiteru Goto, Masashi Fukayama, Chih-Ping Li, Hisataka Uchima, Suguru Yonezawa, Shinichi Kitajima, Jae-Soo Koh, Kun-Tu Yeh, Toshiro Niki |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology medicine.medical_specialty Pathology Asia Lung Neoplasms Esophageal Neoplasms Genotype Polymerase Chain Reaction Virology Internal medicine Prevalence medicine Carcinoma Humans Lung cancer Papillomaviridae In Situ Hybridization Aged Aged 80 and over Esophageal disease business.industry Papillomavirus Infections Respiratory disease HPV infection virus diseases Cancer Middle Aged Esophageal cancer medicine.disease Infectious Diseases Adenocarcinoma Female business |
| Zdroj: | Journal of Medical Virology. 83:1383-1390 |
| ISSN: | 0146-6615 |
| DOI: | 10.1002/jmv.22150 |
| Popis: | The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter-laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV. |
| Databáze: | OpenAIRE |
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