Renal carcinogenesis in the Eker rat

Autor: O. Hino, E. Kobayashi, M. Nishizawa, Y. Kubo, T. Kobayashi, Y. Hirayama, S. Takai, Y. Kikuchi, H. Tsuchiya, K. Orimoto, K. Kajino, T. Takahara
Rok vydání: 1995
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 121:602-605
ISSN: 1432-1335
0171-5216
DOI: 10.1007/bf01197777
Popis: The Eker rat hereditary renal carcinoma is an excellent example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We recently reported that a germline insertion in the rat homologue of the human tuberous sclerosis (TSC2) gene gives rise to the dominantly inherited cancer in the Eker rat model. The function of the TSC2/Tsc2 gene product (called "tuberine" in the human case) is not yet understood, although it contains a short amino acid sequence homologous to the ras family GTPase-activating proteins (GAP3). In the study, we isolated subtracted cDNA clones having increased expression in Eker renal carcinoma cells, using a modified representational difference analysis method to search for additional genes specifically involved in renal carcinogenesis. Here we identified four genes: the third component of the complement (C3) gene, the fos-related antigen I (fra-1) gene, an unknown gene (designated as being expressed in renal carcinoma: erc) and the calpactine I heavy-chain (Annexin II) gene.
Databáze: OpenAIRE
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