Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss
| Autor: | Ruth I. Versteeg, Aart J. Nederveen, Ellen A. Fliers, Mireille J. Serlie, S E la Fleur, Mariëtte T. Ackermans |
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| Přispěvatelé: | Other departments, Other Research, Laboratory for Endocrinology, ACS - Amsterdam Cardiovascular Sciences, AMS - Amsterdam Movement Sciences, Radiology and Nuclear Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, ANS - Cellular & Molecular Mechanisms, ACS - Diabetes & metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty Magnetic Resonance Spectroscopy Diet Reducing Endocrinology Diabetes and Metabolism Treatment outcome Medicine (miscellaneous) 030209 endocrinology & metabolism law.invention 03 medical and health sciences 0302 clinical medicine Text mining Randomized controlled trial Weight loss law Internal medicine Weight Loss medicine Humans Obesity Meals Triglycerides Aged Meal Nutrition and Dietetics business.industry digestive oral and skin physiology Insulin sensitivity Glucose clamp technique Middle Aged 030104 developmental biology Endocrinology Liver metabolism Treatment Outcome Liver Glucose Clamp Technique medicine.symptom Insulin Resistance business Energy Intake Energy Metabolism |
| Zdroj: | International journal of obesity (2005), 42(2), 156-162. Nature Publishing Group |
| ISSN: | 0307-0565 |
| DOI: | 10.1038/ijo.2017.199 |
| Popis: | BACKGROUND: Several human and rodent studies suggest that in addition to the amount of energy consumed, timing of food intake contributes to body weight regulation. Consuming most energy in the morning has favorable effects on weight loss and weight maintenance. Whether this also affects glucose metabolism and liver fat independently from weight loss is unknown. OBJECTIVE: We hypothesized that during weight loss, consuming most energy in the morning improves insulin sensitivity and reduces hepatic fat content more than consuming most energy in the evening. METHODS: Twenty-three obese insulin resistant men (age 59.9 +/- 7.9 years, body mass index 34.4 +/- 3.8 kg m(-2)) followed a 4-week hypocaloric diet intervention with either 50% of daily energy consumed in the morning (BF group) or evening (D group). Insulin sensitivity, measured with a two-step hyperinsulinemic euglycemic clamp using a glucose tracer, intrahepatic triglycerides (IHTG), measured using magnetic resonance spectroscopy, and resting energy expenditure (REE) were assessed before and after the diet intervention. RESULTS: Meal macronutrient composition and weight loss (6.5 +/- 1.5% vs 6.2 +/- 1.9%, respectively, P = 0.70) did not differ between the BF and D groups. Endogenous glucose production (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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