Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded intra-individual prospective study
| Autor: | Lina Mirić Kovačević, Dubravka Vuković, Vesna Čapkun, Antoanela Čarija, Neira Puizina-Ivić |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Radiation-Sensitizing Agents Skin Neoplasms medicine.medical_treatment Biophysics Urology Lasers Dye Photodynamic therapy Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Light source medicine Humans Pharmacology (medical) Basal cell Single-Blind Method Prospective Studies Low-Level Light Therapy Prospective cohort study Aged business.industry Therapeutic effect Cancer Pain Middle Aged Intra individual Combined Modality Therapy eye diseases Confidence interval Surgery ALA-photodynamic therapy BCC Non-melanoma skin cancers PDL Pulsed-dye laser-mediated photodynamic therapy Treatment Outcome Oncology Photochemotherapy Carcinoma Basal Cell 030220 oncology & carcinogenesis Total dose Female business |
| Popis: | Background and objective To compare a single treatment of PDL-PDT with PDT for BCCs in terms of efficacy, aesthetic outcome, and pain in patients with multiple BCCs. Study Design/Materials and methods A prospective, controlled, intra-individual, investigator-blinded study was conducted on 15 patients with 62 BCCs. The BCCs on an individual patient were divided into two similarly-sized groups, and treated with PDT (630 nm LED light source, fluence rate = 30 mW/cm 2 , total dose of 150 J/cm 2 ) and 585 nm-PDL-PDT (spot size = 7 mm, fluence = 10 J/cm 2 , pulse duration = 10 ms, 10% overlap, three passes, and cooling). Primary outcomes were complete BCC regression at months 3 and 12. Secondary outcomes were pain immediately after treatment, and aesthetic outcome evaluated by a blinded investigator. Results No significant difference was found in the therapeutic effect between the two treatments ( P = 0.285). Complete regression of BCCs at 3-months follow-up occurred in 79% of the PDT treated area and 74% of the PDL-PDT area. At month 12, complete regression using PDT was 75% (95% confidence interval (CI) 0.55–0.89) compared to 59% (95% CI 0.41–0.75) for the PDL-PDT treated areas. Both treatments had low mean pain scores: 1.7 for PDT and 2.6 for PDL-PDT ( P = 0.049) and the aesthetic appearance was similar ( P = 0.763). Conclusion A single treatment with three passes of PDL-PDT is effective in clearing BCCs, but the recurrence rate is higher than in case of conventional PDT. PDL-PDT is associated with low treatment related pain, has similar cosmetic advantages as PDT but it requires less treatment time. |
| Databáze: | OpenAIRE |
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