Habitual cigarette smoking attenuates shear‐mediated dilation in the brachial artery but not in the carotid artery in young adults
| Autor: | Kazunori Kato, Takuro Washio, Shingo Tsukamoto, Erika Iwamoto, Kazuya Suzuki, Shigehiko Ogoh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty Brachial Artery Physiology internal carotid artery Ageing and Degeneration 030204 cardiovascular system & hematology Cardiovascular Physiology lcsh:Physiology Neurological Conditions Disorders and Treatments 03 medical and health sciences Cerebral circulation Young Adult 0302 clinical medicine shear rate endothelial function nitric oxide Physiology (medical) medicine.artery Internal medicine medicine Tobacco Smoking Humans cardiovascular diseases Brachial artery Young adult Reactive hyperemia Original Research reactive oxygen species lcsh:QP1-981 business.industry Area under the curve Peripheral Vasodilation Cardiology cardiovascular system Female Internal carotid artery medicine.symptom business Hypercapnia Toxins Pollutants and Chemical Agents 030217 neurology & neurosurgery Blood Flow Velocity Carotid Artery Internal circulatory and respiratory physiology |
| Zdroj: | Physiological Reports Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020) |
| ISSN: | 2051-817X |
| Popis: | In the present study, we hypothesized that habitual cigarette smoking attenuates endothelial function in the cerebral circulation as well as that of the peripheral circulation in young adults. To test this hypothesis, we measured cerebrovascular and peripheral flow‐mediated dilation (FMD) in young smokers and nonsmokers in the present study. Ten healthy nonsmokers and 10 smokers participated in the study. We measured blood velocity and diameter in the brachial artery and internal carotid artery (ICA) using Doppler ultrasound. We identified shear‐mediated dilation in the brachial artery and ICA by the percentage change in peak diameter during hyperemia stimulation (reactive hyperemia and hypercapnia). We measured the baseline diameter and the shear rate area under the curve from the onset of hyperemia to peak dilation in the brachial artery and ICA, finding the measurements of the smokers and those of the nonsmokers did not differ (p > .05). In contrast to brachial FMD (5.07 ± 1.79% vs. 7.92 ± 3.01%; smokers vs. nonsmokers, p = .019), FMD in the ICA was not attenuated in the smokers compared with that of the nonsmokers (5.46 ± 2.32% vs. 4.57 ± 2.70%; p = .442). These findings indicate that in young healthy smokers, cerebral endothelial function was preserved, and the response of cerebral endothelial function to smoking was different from that of peripheral vasculature. Peripheral FMD was lower in young healthy smokers than that in nonsmokers, indicating that habitual smoking attenuates peripheral endothelial function. In contrast, cerebral endothelial function was preserved in young healthy smokers. These findings suggest that the response of cerebral endothelial function to smoking is different from that of peripheral vasculature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|