In-hospital mortality rates and HIV: a medical ward review, Lilongwe, Malawi
Autor: | Dan Namarika, A Akinkuotu, E Roemer, Irving F. Hoffman, Amy Richardson, A Bahling, Charles K. Munthali, Mina C. Hosseinipour |
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Rok vydání: | 2011 |
Předmět: |
Adult
Male Malawi Pediatrics medicine.medical_specialty Population HIV Infections Dermatology Logistic regression Acquired immunodeficiency syndrome (AIDS) Odds Ratio medicine Humans Pharmacology (medical) Medical ward Hospital Mortality Prospective Studies Prospective cohort study education education.field_of_study AIDS-Related Opportunistic Infections business.industry Public Health Environmental and Occupational Health Odds ratio Middle Aged medicine.disease Confidence interval Logistic Models Infectious Diseases Anti-Retroviral Agents Female Observational study business |
Zdroj: | International Journal of STD & AIDS. 22:465-470 |
ISSN: | 1758-1052 0956-4624 |
Popis: | In order to determine inpatient hospital mortality rates, causes of mortality and characteristics of inpatients at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi, we conducted a prospective observational study of all patients admitted to KCH medical ward from 20 September 2008 to April 2, 2009. All admission diagnoses, HIV status and antiretroviral therapy (ART) use were recorded. Patients' vital status was determined at discharge. A descriptive analysis and two logistic regression models were used for the analysis. Of the 1895 enrolled patients, the overall hospital mortality rate was 14.6%, substantially higher among known HIV-infected patients (24.2% versus 10.8%, P = 0.0009) and men (17.1% versus 12%, P = 0.033). Patients with multiple diagnoses had significantly higher mortality (odds ratio [OR] 2.33; 95% confidence interval [CI] 1.47, 3.71). Most patients (62.3%) had unknown HIV status at admission. Among HIV-infected patients, ART use did not reduce hospital mortality or alter the spectrum of diseases. The majority of diagnoses were infectious (63.4%). The high inpatient mortality rate, especially among HIV-infected patients combined with the limited spectrum of diagnoses, emphasizes the need for improved inpatient management and diagnostic services. Expansion of HIV testing is warranted. Despite the rollout of ART, there remains a significant need for treatment of HIV-infected individuals. |
Databáze: | OpenAIRE |
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