Gonadotrophin response to LH-RH in boys with delayed growth and adolescence
| Autor: | M O Savage, Michael A. Preece, J Jones, J L Penfold, James M. Tanner, G Theintz, Noel Cameron |
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| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Pituitary Function Tests Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone Basal (phylogenetics) Follicle-stimulating hormone Age Determination by Skeleton Internal medicine Humans Medicine Child Growth Disorders Puberty Delayed Dose-Response Relationship Drug business.industry Puberty Bone age Luteinizing Hormone Body Height Endocrinology Pediatrics Perinatology and Child Health Delayed growth Follicle Stimulating Hormone Growth delay business Luteinizing hormone Research Article Hormone |
| Zdroj: | Archives of Disease in Childhood. 56:552-556 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.56.7.552 |
| Popis: | Plasma luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations were measured before and after intravenous luteinising hormone-releasing hormone (LH-RH) in 33 boys with growth delay. Eighteen were prepubertal and 15 pubertal. Basal LH and FSH levels were low in both groups with mean increments after LH-RH of 3.2 +/- 0.8 U/l (mean +/- SEM) and 2.6 +/- 0.4 U/l respectively in the prepubertal and 7.4 +/- 0.7 U/l and 2.0 +/- 0.3 U/l in the pubertal boys. The LH increment showed a positive correlation with increasing bone age (r = 0.71, P less than 0.001); FSH did not. The LH-RH response thus appeared normal in relation to the stage of maturity. |
| Databáze: | OpenAIRE |
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