Primeira descrição da caracterização fenotípica e susceptibilidade in vitro a drogas de leveduras do gênero Cryptococcus spp isoladas de pacientes HIV positivos e negativos, Estado de Mato Grosso
| Autor: | Cor Jesus Fernandes Fontes, Luciano Correa Ribeiro, Tomoko Tadano, Flávio Basili Dias, Rosane Christine Hahn, Bruno Pereira Albuquerque Coelho, Olivia Cometti Favalessa |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Cryptococcus neoformans Voriconazole Cryptococcus spp biology Itraconazole Cryptococcus HIV bacterial infections and mycoses biology.organism_classification Virology Microbiology Mato Grosso Infectious Diseases Amphotericin B medicine Drogas antifúngicas Parasitology Ketoconazole Cryptococcus gattii Fluconazole medicine.drug |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.42 n.6 2009 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
| ISSN: | 0037-8682 |
| DOI: | 10.1590/s0037-86822009000600010 |
| Popis: | Thirty-seven isolates from 10 HIV-negative and 26 HIV-positive patients in Mato Grosso were evaluated. Direct examination, culturing and chemotyping of species were performed. Ketoconazole, itraconazole, voriconazole, fluconazole and amphotericin B were evaluated. Thirty-seven yeasts of Cryptococcus spp were identified, of which 26 were from HIV-positive patients (25 Cryptococcus neoformans and one Cryptococcus gattii) and 10 from HIV-negative patients (five Cryptococcus neoformans and five Cryptococcus gattii). The Cryptococcus neoformans clinical isolates from HIV-positive patients showed resistance (8% and 8.7%) and dose-dependent susceptibility (20% and 17.4%) to fluconazole and itraconazole, respectively. Among the Cryptococcus neoformans isolates from HIV-negative patients, there was dose-dependent susceptibility (40%) to fluconazole. Cryptococcus gattii isolates from HIV-negative patients were shown to be susceptible to all antifungal agents, except for one isolate of Cryptococcus gattii that showed dose-dependent susceptibility to fluconazole (20%). The Cryptococcus gattii isolate from an HIV-positive patient showed resistance to fluconazole (MIC > 256 ¼g/ml) and itraconazole (MIC = 3 ¼g/ml). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|