Spread of scrapie agent to the central nervous system: study of a rat model
| Autor: | Marie-Hele`ne Bassant, Henry Baron, Françoise Cathala, Louis Court, M. Gumpel |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Central Nervous System
Male Pathology medicine.medical_specialty Prions Rat model Central nervous system Time lag Scrapie Biology medicine Animals Peripheral Nerves Molecular Biology General Neuroscience Brain Electroencephalography Rats Inbred Strains Scrapie agent Hematogenous Spread Rats Peripheral medicine.anatomical_structure Immunology Neurology (clinical) Sciatic nerve Sleep Developmental Biology |
| Zdroj: | Brain Research. 383:397-401 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(86)90048-x |
| Popis: | Invasion of scrapie agent into the central nervous system (CNS) was studied in rats following intracerebral and peripheral inoculation, the latter by injection into intact or transected sciatic nerve. Comparison of sleep-wakefulness alterations, neuropathological features, and time lag of electroencephalographic and clinical signs in the 3 groups suggests that hematogenous spread of infection to the CNS may predominate over neural transport, and that peripheral inoculation may closely approximate natural infection. |
| Databáze: | OpenAIRE |
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