Increasing the Efficiency of Parkinson's Disease Treatment Using a poly(lactic-co-glycolic acid) (PLGA) Based L-DOPA Delivery System
| Autor: | I.G. Kondrasheva, A. A. Guseva, P.Y. Gambaryan, E.S. Severin, A.A. Kamensky |
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| Rok vydání: | 2014 |
| Předmět: |
Drug
Parkinson's disease media_common.quotation_subject L-DOPA Pharmacology Cellular and Molecular Neuroscience chemistry.chemical_compound nano-DOPA medicine Glycolic acid media_common Benserazide business.industry PLGA medicine.disease animal models Motor coordination Bioavailability nervous system diseases chemistry nasal administration Nasal administration Original Article Neurology (clinical) business medicine.drug |
| Zdroj: | Experimental Neurobiology |
| ISSN: | 1226-2560 |
| Popis: | To compare the efficacy of L-DOPA administered intranasally in the form of nanoparticles (nano-DOPA) and in standard drug forms using a rat Parkinson's Disease (PD) model. L-DOPA-containing nanoparticles (250±50 nm) were synthesized using the double emulsion method. The efficacy of nano-DOPA therapy was studied in Wistar rats with 6-OHDA-induced PD. Drugs were administered daily, 0.35 mg/kg (by L-DOPA). Animals' motor coordination and behavior were analyzed using the forelimb placing task and several other tests. Thirty minutes after the first administration, animals treated with L-DOPA, L-DOPA+benserazide, and nano-DOPA showed equally significant (p |
| Databáze: | OpenAIRE |
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