Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status

Autor:	Anne P. Hutchinson, Ping Yin, Ilona Neale, John S. Coon, Stacy A. Kujawa, Shimeng Liu, Serdar E. Bulun
Rok vydání:	2021
Předmět:	Adult Gene Expression Regulation Neoplastic Mediator Complex Leiomyoma Mutation Tumor Cells Cultured Obstetrics and Gynecology Humans Female Middle Aged Progestins female genital diseases and pregnancy complications Tryptophan Oxygenase
Zdroj:	Reproductive sciences (Thousand Oaks, Calif.). 29(3)
ISSN:	1933-7205
Popis:	Uterine leiomyomas (fibroids) are common benign tumors in women. The tryptophan metabolism through the kynurenine pathway plays important roles in tumorigenesis in general. Leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) were reported to contain significantly decreased tryptophan levels; the underlying mechanism and the role of the tryptophan metabolism-kynurenine pathway in leiomyoma tumorigenesis, however, remain unknown. We here assessed the expression and regulation of the key enzymes that metabolize tryptophan. Among these, the tissue mRNA levels of tryptophan 2,3-dioxygenase (TDO2), the rate limiting enzyme of tryptophan metabolism through the kynurenine pathway, was 36-fold higher in mut-MED12 compared to adjacent myometrium (P P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ad95db48decbed9c114245985e6b18 https://pubmed.ncbi.nlm.nih.gov/35064560 Zobrazit plný text záznamu Full text from SpringerLink