Development of a standardized MRI protocol for pancreas assessment in humans

Autor: Jonathan M. Williams, Daniel J. Moore, Richard C. Craddock, Andrea K. Steck, Melissa A. Hilmes, Hakmook Kang, Liping Du, Jeffrey H. Maki, Milica Medved, Michaela Waibel, Siri Atma W. Greeley, Jordan J. Wright, Thomas W.H. Kay, Alvin C. Powers, John Virostko, Helen E. Thomas, Mara Kinney, Taylor M. Triolo
Rok vydání: 2021
Předmět:
Male
Image Processing
Biochemistry
Diagnostic Radiology
Fats
Endocrinology
Medical Conditions
Image Processing
Computer-Assisted
Medicine and Health Sciences
Medicine
Prospective Studies
Multidisciplinary
medicine.diagnostic_test
Phantoms
Imaging
Radiology and Imaging
Software Engineering
Magnetic Resonance Imaging
Lipids
Healthy Volunteers
Type 2 Diabetes
medicine.anatomical_structure
Engineering and Technology
Female
Anatomy
Pancreas
Research Article
Adult
Computer and Information Sciences
Imaging Techniques
Endocrine Disorders
Science
Endocrine System
Neuroimaging
Image processing
Research and Analysis Methods
Computer Software
Exocrine Glands
Diagnostic Medicine
Diabetes Mellitus
Humans
Effective diffusion coefficient
Magnetization transfer
Protocol (science)
Reproducibility
business.industry
Reproducibility of Results
Biology and Life Sciences
Magnetic resonance imaging
Diffusion Magnetic Resonance Imaging
Metabolic Disorders
Signal Processing
business
Nuclear medicine
Neuroscience
Zdroj: PLoS ONE, Vol 16, Iss 8, p e0256029 (2021)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0256029
Popis: Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Calibrated phantoms with known MRI properties were imaged at five sites with differing MRI hardware and software to develop a harmonized MRI imaging protocol. Subsequently, five healthy volunteers underwent MRI at four sites using the harmonized protocol to assess pancreas size, shape, apparent diffusion coefficient (ADC), longitudinal relaxation time (T1), magnetization transfer ratio (MTR), and pancreas and hepatic fat fraction. Following harmonization, pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time were reproducible, with coefficients of variation less than 10%. In contrast, non-standardized image processing led to greater variation in MRI measurements. By using a standardized MRI image acquisition and processing protocol, quantitative MRI of the pancreas performed at multiple locations can be incorporated into clinical trials comparing pancreas imaging measures and metabolic state in individuals with type 1 or type 2 diabetes.
Databáze: OpenAIRE
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