Antimicrobial and anthelmintic activities of the ethanolic extract, fractions and isolated compounds from Manilkara zapota L. P. Royen (Sapotaceae)

Autor: Layany Carolyny Mourão Mulvaney, Vera Lúcia Garcia, Alice M. S. Rodrigues, Francisco Humberto Xavier-Júnior, Didier Stien, Silmara Marques Allegretti
Přispěvatelé: University of Campinas [Campinas] (UNICAMP), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Universidade Potiguar, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), PIERRE FABRE-EDF (EDF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2020
Předmět:
Male
Staphylococcus aureus
Phytochemistry
Antifungal Agents
Pharmaceutical Science
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
Manilkara
Gas Chromatography-Mass Spectrometry
03 medical and health sciences
chemistry.chemical_compound
Phytomedicine
0302 clinical medicine
Chlorogenic acid
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Candida albicans
Strongyloides
medicine
Animals
Anthelmintic
Rats
Wistar
030304 developmental biology
Pharmacology
Anthelmintics
0303 health sciences
biology
Traditional medicine
anthelmintic
Plant Extracts
Arthrodermataceae
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
biology.organism_classification
Antimicrobial
Sapotaceae
Bioactive compound
Anti-Bacterial Agents
Rats
Plant Leaves
chemistry
030220 oncology & carcinogenesis
Traditional medicine Meso- and Southern America
phytochemistry
antimicrobial
chromatography
Female
medicine.drug
Zdroj: Journal of Pharmacy and Pharmacology
Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, 2021, 73, pp.377-387. ⟨10.1093/jpp/rgaa030⟩
ISSN: 2042-7158
0022-3573
Popis: Objectives To evaluate the antibacterial, antifungal and anthelmintic activities of the ethanolic extract (EEMz), fractions (LPFMz and HPFMz) and compounds isolated from the leaves of Manilkara zapota L. P. Royen. Methods Extract and fractions were produced by turbolization. LPFMz fraction was analysed by gas chromatography–mass spectrometry. The isolated compounds from HPFMz were purified by flash and preparative chromatographic methods, and chemically characterised by UPLC-ESITOFMS, optical rotation, and one- and two-dimensional 1H and 13C NMR techniques. Anthelmintic against Strongyloides venezuelensis and antimicrobial activities against Candida albicans, Trichophyton rubrum and Staphylococcus aureus were evaluated. Key findings EEMz showed mainly phenolic compounds and pentacyclic triterpenes from Δ12-oleane/Δ12-ursane series. Chlorogenic acid, myricetin-3-O-β-D-glucopyranoside, mearnsitrin, germanicol and germanicol acetate were reported to M. zapota leaves for the first time in this work. EEMz, HPFMz, LPFMz showed significative activity against C. albicans (16 µg/mL), while isolated flavonoids were active against S. aureus ( Conclusions M. zapota and its bioactive compound can be eligible such as a potential phytomedicine for the treatment of microbial and strongyloidiasis drug-resistant infections.
Databáze: OpenAIRE
Externí odkaz: