Antimicrobial and anthelmintic activities of the ethanolic extract, fractions and isolated compounds from Manilkara zapota L. P. Royen (Sapotaceae)
Autor: | Layany Carolyny Mourão Mulvaney, Vera Lúcia Garcia, Alice M. S. Rodrigues, Francisco Humberto Xavier-Júnior, Didier Stien, Silmara Marques Allegretti |
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Přispěvatelé: | University of Campinas [Campinas] (UNICAMP), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Universidade Potiguar, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), PIERRE FABRE-EDF (EDF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
Rok vydání: | 2020 |
Předmět: |
Male
Staphylococcus aureus Phytochemistry Antifungal Agents Pharmaceutical Science [CHIM.THER]Chemical Sciences/Medicinal Chemistry Manilkara Gas Chromatography-Mass Spectrometry 03 medical and health sciences chemistry.chemical_compound Phytomedicine 0302 clinical medicine Chlorogenic acid [CHIM.ANAL]Chemical Sciences/Analytical chemistry Candida albicans Strongyloides medicine Animals Anthelmintic Rats Wistar 030304 developmental biology Pharmacology Anthelmintics 0303 health sciences biology Traditional medicine anthelmintic Plant Extracts Arthrodermataceae [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences biology.organism_classification Antimicrobial Sapotaceae Bioactive compound Anti-Bacterial Agents Rats Plant Leaves chemistry 030220 oncology & carcinogenesis Traditional medicine Meso- and Southern America phytochemistry antimicrobial chromatography Female medicine.drug |
Zdroj: | Journal of Pharmacy and Pharmacology Journal of Pharmacy and Pharmacology, Royal Pharmaceutical Society of Great Britain, 2021, 73, pp.377-387. ⟨10.1093/jpp/rgaa030⟩ |
ISSN: | 2042-7158 0022-3573 |
Popis: | Objectives To evaluate the antibacterial, antifungal and anthelmintic activities of the ethanolic extract (EEMz), fractions (LPFMz and HPFMz) and compounds isolated from the leaves of Manilkara zapota L. P. Royen. Methods Extract and fractions were produced by turbolization. LPFMz fraction was analysed by gas chromatography–mass spectrometry. The isolated compounds from HPFMz were purified by flash and preparative chromatographic methods, and chemically characterised by UPLC-ESITOFMS, optical rotation, and one- and two-dimensional 1H and 13C NMR techniques. Anthelmintic against Strongyloides venezuelensis and antimicrobial activities against Candida albicans, Trichophyton rubrum and Staphylococcus aureus were evaluated. Key findings EEMz showed mainly phenolic compounds and pentacyclic triterpenes from Δ12-oleane/Δ12-ursane series. Chlorogenic acid, myricetin-3-O-β-D-glucopyranoside, mearnsitrin, germanicol and germanicol acetate were reported to M. zapota leaves for the first time in this work. EEMz, HPFMz, LPFMz showed significative activity against C. albicans (16 µg/mL), while isolated flavonoids were active against S. aureus ( Conclusions M. zapota and its bioactive compound can be eligible such as a potential phytomedicine for the treatment of microbial and strongyloidiasis drug-resistant infections. |
Databáze: | OpenAIRE |
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