Advances in targeting acquired resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors
| Autor: | Jonathan W. Riess, Justin A. Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Review Article on Mechanisms of Resistance to EGFR-targeted Therapy biology business.industry Drug resistance medicine.disease respiratory tract diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Acquired resistance Epidermal growth factor 030220 oncology & carcinogenesis medicine Cancer research biology.protein Carcinoma Epidermal growth factor receptor Lung cancer Receptor business Epidermal growth factor receptor tyrosine kinase |
| Zdroj: | J Thorac Dis |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2019.08.32 |
| Popis: | Next-generation sequencing (NGS) of tumor samples and circulating tumor DNA has revolutionized diagnostic and therapeutic strategies in lung cancer. The identification of the epidermal growth factor receptor (EGFR) oncogenic driver has translated into successful therapy of advanced lung cancer using EGFR tyrosine kinase inhibitors (TKI). Unfortunately, responses are limited by acquired mechanisms of resistance. We review herein the current landscape of acquired resistance mechanisms to EGFR-TKI therapy and recent advances in therapeutic strategies to overcome acquired resistance. |
| Databáze: | OpenAIRE |
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