Plasma 5α–androstane–3α,17βdiol, an endogenous steroid that positively modulates GABAA receptor function, and anxiety: a study in menopausal women
| Autor: | C Romanini, T Cocco, A Cocchiarale, M Trabucchi, Maria Luisa Barbaccia, S Lello, V Piermarini, R.P Sorge, A.F Sabato, T Sidiropoulou |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Neuroactive steroid Personality Inventory Endocrinology Diabetes and Metabolism Dehydroepiandrosterone Anxiety Asymptomatic Endocrinology Internal medicine Etiocholanolone medicine Humans Receptor Biological Psychiatry Climacteric Depression Endocrine and Autonomic Systems GABAA receptor Middle Aged Receptors GABA-A medicine.disease Menopause Psychiatry and Mental health Female medicine.symptom Psychology Body mass index |
| Zdroj: | Psychoneuroendocrinology. 25:659-675 |
| ISSN: | 0306-4530 |
| Popis: | We tested the hypothesis that changes in endogenous neuroactive steroids acting as positive allosteric modulators of gamma-aminobutyric acid (GABA)(A) receptors may be related to the menopause-associated mood alterations. The study sample consisted of twenty five drug-free menopausal women, 1-3 years since the onset of menopause, homogeneous for age and body mass index (BMI) and without personal history of psychiatric, metabolic or endocrine disorders. Depression and anxiety-related symptoms were assessed with the Zung Self-administered Depression Scale (ZSDS) and the Cornell's Dysthymia Rating Scale (CDRS). The cut-off value predicted by the ZSDS index defined two groups of women (asymptomatic [35.5+/-4.6, n=12] and symptomatic [60.8+/-7.9, n=13]), that were also significantly different according to the CDRS scores (10.6+/-3.4 and 31.5+/-12, respectively, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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