Mechanisms involved in the regulation of histone lysine demethylases
| Autor: | Amanda C. Nottke, Fei Lan, Yang Shi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Histone Demethylases
Oxidoreductases N-Demethylating Cell Biology Biology Methylation Article Epigenesis Genetic DNA-Binding Proteins Histones Gene Expression Regulation Histone H1 Biochemistry Histone methyltransferase Histone methylation Histone H2A biology.protein Animals Humans Histone code Demethylase JARID1B Protein Processing Post-Translational Transcription Factors |
| Zdroj: | Current Opinion in Cell Biology. 20:316-325 |
| ISSN: | 0955-0674 |
| DOI: | 10.1016/j.ceb.2008.03.004 |
| Popis: | Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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