Extent of heterogeneity in mitochondrial DNA of ethnic Asian populations
| Autor: | Mark Stoneking, Terry Melton |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Genetics
Mitochondrial DNA education.field_of_study Analysis of Variance Chi-Square Distribution Population Ethnic group Population genetics Locus (genetics) Biology Analysis of molecular variance DNA Mitochondrial Pathology and Forensic Medicine Genetic Heterogeneity Asian People Evolutionary biology Geographical distance Humans Typing education |
| Zdroj: | Journal of forensic sciences. 41(4) |
| ISSN: | 0022-1198 |
| Popis: | Variation in the mitochondrial DNA (mtDNA) control region as detected by sequence-specific oligonucleotide (SSO) probes is described for 993 individuals in 11 ethnic Asian populations. Estimates of diversity for mtDNA types exceed 0.94 in all populations, while 53% of the 255 types that were observed occur only once. Of 96 shared types, four occur at frequencies of greater than 10% but less than 17% in any one population. There is statistically significant heterogeneity among these 11 populations, however, an analysis of variance incorporating genetic distances between types shows that at least 95% of the variation present in the total sample is attributable to within-population diversity, while only 5% is due to between-population differences. Overall, heterogeneity with respect to mtDNA SSO types is grossly correlated with geographic distance between populations; the most extreme heterogeneity was observed between populations from East Asia and populations from West Asia. With respect to population genetics, the control region of mtDNA exhibits satisfactory qualities as a DNA typing locus. |
| Databáze: | OpenAIRE |
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