Application of the MISTEACHING(S) disease susceptibility framework to Actinobacillus pleuropneumoniae to identify research gaps: an exemplar of a veterinary pathogen
| Autor: | Janine T. Bossé, Paul R. Langford, Oliver W Stringer, Yanwen Li |
|---|---|
| Přispěvatelé: | Biotechnology and Biological Sciences Research Council (BBSRC), Biotechnology and Biological Sciences Research Council |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Veterinary medicine 030106 microbiology MISTEACHINGS Human pathogen ENDOBRONCHIAL INOCULATION CONFERS PROTECTION 03 medical and health sciences Disease susceptibility RESPIRATORY-DISEASES PIGS Veterinary Sciences MICROBIAL COMMUNITIES Microbiome HAEMOPHILUS Actinobacillus pleuropneumoniae Pathogen Science & Technology biology 0707 Veterinary Sciences disease susceptibility IN-VITRO biology.organism_classification infection 030104 developmental biology NUTRITIONAL IMMUNITY VIRULENCE Animal Science and Zoology Identification (biology) Life Sciences & Biomedicine Damage Response Framework |
| Zdroj: | Animal Health Research Reviews. 22:120-135 |
| ISSN: | 1475-2654 1466-2523 |
| DOI: | 10.1017/s1466252321000074 |
| Popis: | Historically, the MISTEACHING (microbiome, immunity, sex, temperature, environment, age, chance, history, inoculum, nutrition, genetics) framework to describe the outcome of host−pathogen interaction, has been applied to human pathogens. Here, we show, using Actinobacillus pleuropneumoniae as an exemplar, that the MISTEACHING framework can be applied to a strict veterinary pathogen, enabling the identification of major research gaps, the formulation of hypotheses whose study will lead to a greater understanding of pathogenic mechanisms, and/or improved prevention/therapeutic measures. We also suggest that the MISTEACHING framework should be extended with the inclusion of a ‘strain’ category, to become MISTEACHINGS. We conclude that the MISTEACHINGS framework can be applied to veterinary pathogens, whether they be bacteria, fungi, viruses, or parasites, and hope to stimulate others to use it to identify research gaps and to formulate hypotheses worthy of study with their own pathogens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|