Immunohistochemical analysis of neutrophils, interleukin‐17, matrix metalloproteinase‐9, and neoformed vessels in oral squamous cell carcinoma
| Autor: | Aline Carvalho Batista, Ana Karoline De Carvalho Araújo, Ricardo Natã Fonseca Silva, Tarcília Aparecida Silva, Laís Bueno Dallarmi, Elismauro Francisco Mendonça, Nádia Lago Costa, Rita de Cássia Gonçalves Alencar |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research Pathology medicine.medical_specialty Neutrophils Angiogenesis Inflammation GPI-Linked Proteins Malignancy Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Antigens CD Biomarkers Tumor medicine Humans Oral mucosa Neovascularization Pathologic business.industry Interleukin-17 Endoglin Middle Aged Prognosis medicine.disease Immunohistochemistry stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Matrix Metalloproteinase 9 Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Periodontics Female Mouth Neoplasms Interleukin 17 Oral Surgery medicine.symptom business Cell Adhesion Molecules |
| Zdroj: | Journal of Oral Pathology & Medicine. 47:856-863 |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/jop.12762 |
| Popis: | BACKGROUND Tumor-associated neutrophils (TAN), matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17), and angiogenesis have been proposed as prognostic biomarkers of malignant tumors. The purpose of this study was to investigate these inflammatory markers as prognostic factors for oral squamous cell carcinoma (OSCC). METHODS Specimens of OSCC (n = 30), healthy oral mucosa (negative control, n = 10), oral leukoplakia (n = 10), and apical granuloma with abscess (positive inflammatory controls, n = 10) were immunostained for CD66b (neutrophils), MMP-9, IL-17, and CD105 (neoformed microvessels). Semiquantitative (IL-17) and quantitative (CD66b, IL-17, MMP-9, and CD105) analyses were performed. Clinical information (TNM stage, metastasis, recurrence, and survival) and tumor histological grade were also obtained. RESULTS Positivity for TAN, MMP-9, IL-17, and CD105 was higher in OSCC than in the negative control (P |
| Databáze: | OpenAIRE |
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