Bypass grafts and cell transplant in heart failure with low ejection fraction
| Autor: | Alfonso Rivas-Plata, Ausberto Chunga, Marcos Pariona, Jorge J. Castillo |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Time Factors medicine.medical_treatment Cell Revascularization Ventricular Function Left Ventricular Dysfunction Left Internal medicine Peru medicine Humans Longitudinal Studies Prospective Studies Coronary Artery Bypass Prospective cohort study Aged Bone Marrow Transplantation Heart Failure Ejection fraction business.industry Myocardium Stroke Volume General Medicine Stroke volume Recovery of Function Middle Aged medicine.disease Surgery Transplantation medicine.anatomical_structure Treatment Outcome Heart failure Case-Control Studies Cardiology Female Stem cell Cardiology and Cardiovascular Medicine business Stem Cell Transplantation |
| Zdroj: | Asian cardiovascularthoracic annals. 18(5) |
| ISSN: | 1816-5370 |
| Popis: | From June 2004 to October 2007, 34 patients with chronic heart failure and low ejection fraction underwent surgical revascularization; 23 received bypass grafting plus transplantation of bone marrow-derived stem cells (study group) and 11 had revascularization only (control group). The stem cells were implanted into nonviable myocardial areas, bypass grafting was performed in viable myocardial areas. In the study group, the ejection fraction increased from the baseline 26.4% ± 4% to 37.3% ± 11.5% after 26 months. In the control group, ejection fraction increased from 29% ± 2% to 31.5% ± 4.3% after 27 months. The improvement in the study group was significantly greater than that in the control group. Functional class improved significantly from 3.2 to 1.2 in the study group vs. 3.0 to 2.3 in the control group. Stem cell transplantation associated with bypass grafting is feasible and safe in patients with chronic heart failure with low ejection fractions, and it improves ventricular systolic function and functional class. |
| Databáze: | OpenAIRE |
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