Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos
| Autor: | Tammy Ellis, Richard L. Berg, Anne R. Greenlee |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Mecoprop
Insecticides Agrochemical Health Toxicology and Mutagenesis Developmental toxicity Apoptosis Biology Diquat Toxicology Embryonic and Fetal Development Mice chemistry.chemical_compound Pregnancy Occupational Exposure Animals Humans Drug Interactions Atrazine Fertilizers Dose-Response Relationship Drug Herbicides business.industry Public Health Environmental and Occupational Health Agriculture Environmental Exposure Environmental exposure Pesticide Fungicides Industrial Terbufos Blastocyst chemistry Models Animal Female business Research Article |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp.6774 |
| Popis: | Occupational exposures to pesticides may increase parental risk of infertility and adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, and congenital anomalies. Less is known about residential use of pesticides and the risks they pose to reproduction and development. In the present study we evaluate environmentally relevant, low-dose exposures to agrochemicals and lawn-care pesticides for their direct effects on mouse preimplantation embryo development, a period corresponding to the first 5-7 days after human conception. Agents tested were those commonly used in the upper midwestern United States, including six herbicides [atrazine, dicamba, metolachlor, 2,4-dichlorophenoxyacetic acid (2,4-D)], pendimethalin, and mecoprop), three insecticides (chlorpyrifos, terbufos, and permethrin), two fungicides (chlorothalonil and mancozeb), a desiccant (diquat), and a fertilizer (ammonium nitrate). Groups of 20-25 embryos were incubated 96 hr in vitro with either individual chemicals or mixtures of chemicals simulating exposures encountered by handling pesticides, inhaling drift, or ingesting contaminated groundwater. Incubating embryos with individual pesticides increased the percentage of apoptosis (cell death) for 11 of 13 chemicals (p |
| Databáze: | OpenAIRE |
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