Noninvasive, quantitative evaluation of hepatic steatosis of donor livers by reference frequency method: A preliminary study
| Autor: | Rongqin Zheng, Ping Gong, Chen Qiu, Nana Wang, Qing Yang, Dayang Hui, Shigao Chen, Hongjun Zhang, Yang Yang, Jieyang Jin, Shu-hong Yi, Jie Ren |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry medicine.medical_treatment Ultrasound Diagnostic accuracy General Medicine Gold standard (test) Liver transplantation medicine.disease Gastroenterology Liver Transplantation Fatty Liver Liver ROC Curve Internal medicine medicine Living Donors Humans Radiology Nuclear Medicine and imaging Potential donor Steatosis business Clinical evaluation Retrospective Studies |
| Zdroj: | European journal of radiology. 143 |
| ISSN: | 1872-7727 |
| Popis: | Purpose Evaluating degree of hepatic steatosis is of great value for prognosis of liver transplantation. There is an urgent need for a non-invasive method to assess hepatic steatosis grade of donor livers. Purpose of our study was to evaluate diagnostic accuracy of attenuation coefficient estimation (ACE) by reference frequency method (RFM) in detecting hepatic steatosis of donor livers. Method: We retrospectively enrolled 62 potential liver donors which underwent ACE by RFM ex-vivo, in-vivo or both. We acquired raw data of B-mode images of liver parenchyma and offline-processes for attenuation estimation. Finally, we calculated and compared diagnostic performance of ACEs for steatosis grade detection and used histological results as the gold standard. Results: ACEs with none, mild and moderate hepatic steatosis were 0.57, 0.73 and 0.80 dB/cm/MHz in potential donor livers. The cutoff value to diagnose mild hepatic steatosis was 0.63 dB/cm/MHz and 0.77 dB/cm/MHz for moderate hepatic steatosis, and values for the area under the receiver operating characteristic curve for diagnosis of mild and moderate hepatic steatosis were 0.92 and 0.90, respectively. Conclusions: According to our results, ACE by RFM is an accurate non-invasive method in detecting hepatic steatosis, which may be of great help for clinical evaluation of donor livers before liver transplantation. |
| Databáze: | OpenAIRE |
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