Acid-base and hematological regulation in chicken embryos during internal progressive hypercapnic hypoxia

Autor:	Warren W. Burggren, Sarah J. Andrewartha, Casey A. Mueller, Benjamin Dubansky, Hiroshi Tazawa
Rok vydání:	2022
Předmět:	Pulmonary and Respiratory Medicine Acid-Base Equilibrium Physiology General Neuroscience Alkalosis Chick Embryo Hematology Hypercapnia Hematocrit Animals Acidosis Respiratory Hypoxia Acidosis Chickens
Zdroj:	Respiratory physiologyneurobiology. 308
ISSN:	1878-1519
Popis:	Development of the capacity to mitigate potential disturbances to blood physiology in bird embryos is incompletely understood. We investigated regulation of acid-base and hematology in day 15 chicken embryos exposed to graded intrinsic hypercapnic hypoxia created by varying degrees of water submersion. Metabolic acidosis with additional respiratory or metabolic acidosis occurred at 2 h according to magnitude of submersion. Acid-base disturbance was partially compensated by metabolic alkalosis at 6 h, but compensatory metabolic alkalosis was absent at 24 h. Following submersion with only air cell exposed to air, both hypercapnic respiratory acidosis and metabolic acidosis occurred within 10 min. Subsequently, both forms of acidosis created lethal levels of [HCO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4496c778b6db5298109f8a9b4a334eed https://pubmed.ncbi.nlm.nih.gov/36402363 Zobrazit plný text záznamu Full Text from ScienceDirect