Pathophysiological Mechanisms of Tobacco-Related CVD
| Autor: | Ambuj Roy, Salman Salahuddin, Dorairaj Prabhakaran |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Community and Home Care
medicine.diagnostic_test Epidemiology business.industry Inflammation Disease medicine.disease Toxicology Nicotine Pathogenesis Insulin resistance Immunology medicine Risk factor medicine.symptom Endothelial dysfunction Cardiology and Cardiovascular Medicine Lipid profile business medicine.drug |
| Zdroj: | Global Heart; Vol 7, No 2 (2012); 113-120 |
| ISSN: | 2211-8160 2211-8179 |
| Popis: | Cigarette smoking is a leading preventable risk factor for the development and progression of cardiovascular diseases (CVDs). Epidemiologic studies conclusively prove that both active smoking and secondhand smoke contribute significantly to morbidity and mortality related to CVD. Cigarette smoke is a mixture of several toxic chemicals, of which nicotine, carbon monoxide, and oxidant chemicals are most commonly implicated in the pathogenesis of cardiovascular disease. Tobacco causes endothelial dysfunction, inflammation, insulin resistance, alteration of lipid profile, hemodynamic alterations, and a hypercoagulable state. All of these act synergistically as pathobiologic mechanisms of atherothrombosis in tobacco users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|