Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort
| Autor: | Carlos eAguilar, J-Sebastian eMuehlboeck, Patrizia eMecocci, Bruno eVellas, Magda eTsolaki, Iwona eKloszewska, Hilkka eSoininen, Simon eLovestone, Lars-Olof eWahlund, Andrew eSimmons, Eric eWestman |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Gerontology
Oncology medicine.medical_specialty Aging APOE4 multivariate statistics Cross-sectional study Cognitive Neuroscience OPLS APOE4 Alzheimer disease MCI MRI OPLS multivariate statistics lcsh:RC321-571 Correlation Atrophy Internal medicine mental disorders medicine Original Research Article Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neuropsychology medicine.disease MCI Cohort Alzheimer's disease Alzheimer disease Psychology Alzheimer’s disease Neuroscience MRI |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 6 (2014) |
| Popis: | Cross sectional studies of patients at risk of developing Alzheimer disease (AD) have identified several brain regions known to be prone to degeneration suitable as biomarkers, including hippocampal, ventricular, and whole brain volume. The aim of this study was to longitudinally evaluate an index based on morphometric measures derived from MRI data that could be used for classification of AD and healthy control subjects, as well as prediction of conversion from mild cognitive impairment (MCI) to AD. Patients originated from the AddNeuroMed project at baseline (119 AD, 119 MCI, 110 controls (CTL)) and 1-year follow-up (62 AD, 73 MCI, 79 CTL). Data consisted of 3D T1-weighted MR images, demographics, MMSE, ADAS-Cog, CERAD and CDR scores, and APOE e4 status. We computed an index using a multivariate classification model (AD vs. CTL), using orthogonal partial least squares to latent structures (OPLS). Sensitivity, specificity and AUC were determined. Performance of the classifier (AD vs. CTL) was high at baseline (10-fold cross-validation, 84% sensitivity, 91% specificity, 0.93 AUC) and at 1-year follow-up (92% sensitivity, 74% specificity, 0.93 AUC). Predictions of conversion from MCI to AD were good at baseline (77% of MCI converters) and at follow-up (91% of MCI converters). MCI carriers of the APOE e4 allele manifested more atrophy and presented a faster cognitive decline when compared to non-carriers. The derived index demonstrated a steady increase in atrophy over time, yielding higher accuracy in prediction at the time of clinical conversion. Neuropsychological tests appeared less sensitive to changes over time. However, taking the average of the two time points yielded better correlation between the index and cognitive scores as opposed to using cross-sectional data only. Thus, multivariate classification seemed to detect patterns of AD changes before conversion from MCI to AD and including longitudinal information is of great importance. |
| Databáze: | OpenAIRE |
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