When the Neighboring Village is Not Treated: Role of Geographic Proximity to Communities Not Receiving Mass Antibiotics for Trachoma
| Autor: | Mosenia, Arman, Haile, Berhan A, Shiferaw, Ayalew, Gebresillasie, Sintayehu, Gebre, Teshome, Zerihun, Mulat, Tadesse, Zerihun, Emerson, Paul M, Callahan, E Kelly, Zhou, Zhaoxia, Lietman, Thomas M, Keenan, Jeremy D |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Trachoma
azithromycin geographic information systems Microbiology (medical) mass drug administration ocular chlamydia Clinical Trials and Supportive Activities Infant Chlamydia trachomatis Biological Sciences Medical and Health Sciences Microbiology Anti-Bacterial Agents Good Health and Well Being Infectious Diseases Clinical Research Prevalence Major Article Humans Child Infection Eye Disease and Disorders of Vision |
| Zdroj: | Clin Infect Dis Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 76, iss 6 |
| Popis: | Background Mass administration of azithromycin is an established strategy for decreasing the prevalence of trachoma in endemic areas. However, nearby untreated communities could serve as a reservoir that may increase the chances of chlamydia reinfection in treated communities. Methods As part of a cluster-randomized trial in Ethiopia, 60 communities were randomized to receive mass azithromycin distributions and 12 communities were randomized to no treatments until after the first year. Ocular chlamydia was assessed from a random sample of children per community at baseline and month 12. Distances between treated and untreated communities were assessed from global positioning system coordinates collected for the study. Results The pretreatment prevalence of ocular chlamydia among 0 to 9 year olds was 43% (95% confidence interval [CI], 39%-47%), which decreased to 11% (95% CI, 9%-14%) at the 12-month visit. The posttreatment prevalence of chlamydia was significantly higher in communities that were closer to an untreated community after adjusting for baseline prevalence and the number of mass treatments during the year (odds ratio, 1.12 [95% CI, 1.03-1.22] for each 1 km closer to an untreated community). Conclusions Mass azithromycin distributions to wide, contiguous geographic areas may reduce the likelihood of continued ocular chlamydia infection in the setting of mass antibiotic treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|