Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats
| Autor: | Chuan Zhang, Guo-Cai Lu, Hui-Liang Li, Bo-Jun Yuan, Jia-Hong She, Ning-Ling Sun, Tao Wang, Hua Jiang, Wei-Dong Zhang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Berberine Alkaloids Pharmacology digestive system Antioxidants Rats Sprague-Dawley Superoxide dismutase chemistry.chemical_compound Liver Function Tests Lactate dehydrogenase Drug Discovery medicine Animals Glutathione Transferase Liver injury chemistry.chemical_classification biology Carbon Tetrachloride Poisoning Plant Extracts Superoxide Dismutase Chemistry Glutathione peroxidase Glutathione medicine.disease Malondialdehyde digestive system diseases Rats Liver Biochemistry Carbon tetrachloride biology.protein Lipid Peroxidation Chemical and Drug Induced Liver Injury Crystallization TBIL |
| Zdroj: | Journal of Ethnopharmacology. 117:300-308 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2008.02.010 |
| Popis: | Aim of the study To investigate the protective effects of dehydrocavidine (DC), a main active ingredient of Corydalis saxicola Bunting (Yanhuanglian), on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanisms involved in male Sprague–Dawley rats. Materials and methods Acute hepatotoxicity was induced by CCl4 intoxication in rats. Serum biological analysis, lipid peroxides and antioxidants estimation, histopathological studies were carried out. Results Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total bilirubin (TBIL). In addition, pre- and post-treatment with DC also significantly prevented formation of hepatic malondialdehyde (MDA), depletion of glutathione peroxidase (GPx) and depression of superoxide dismutase (SOD) in the liver of CCl4-intoxicated rats. ALT, AST, LDH, ALP and TBILL levels, as well as MDA, SOD and GPx activities were unaffected in normal rats by treatment with DC alone. GST, a phase II enzyme, had no significant changes during our experiments. Histopathological changes induced by CCl4 were also significantly attenuated by DC treatment in both preventive and curative experiments. Conclusions DC has a potent hepatoprotective effect on CCl4-induced liver injury in rats through its antioxidant activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect