Thromboinflammation in Brain Ischemia
| Autor: | Simon F. De Meyer, Friederike Langhauser, Steffen Haupeltshofer, Christoph Kleinschnitz, Ana I. Casas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Advanced and Specialized Nursing
VON-WILLEBRAND-FACTOR PROTECTS MICE microglia Brain Ischemia Stroke GLYCOPROTEIN-IIB/IIIA FOCAL CEREBRAL-ISCHEMIA inflammation B-CELLS thromboinflammation THROMBO-INFLAMMATION ischemic stroke Humans MAST-CELLS Neurology (clinical) REGULATORY T-CELLS LIMIT CNS INFLAMMATION Cardiology and Cardiovascular Medicine ARTERIAL THROMBOSIS thrombosis |
| Zdroj: | Stroke. 53(5):1487-1499 |
| ISSN: | 0039-2499 |
| Popis: | Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial. |
| Databáze: | OpenAIRE |
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