Vitamin D supplementation affects the IGF system in men after acute exercise
| Autor: | Amy Raswalsky, Richard W. Browne, Rachel L. Darr, Kathleen J. Savage, Mark Baker, Gregory E. Wilding, Todd C Rideout, Peter J. Horvath |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism IGFBP3 030209 endocrinology & metabolism Bench press Insulin-like growth factor-binding protein 03 medical and health sciences 0302 clinical medicine Endocrinology Muscle Stretching Exercises Internal medicine medicine Vitamin D and neurology Humans Aerobic exercise IGFBP1 Insulin-Like Growth Factor I Vitamin D Leg press Exercise Cholecalciferol biology business.industry Muscle weakness Resistance Training Vitamins Middle Aged Vitamin D Deficiency Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 3 030104 developmental biology Dietary Supplements biology.protein medicine.symptom business |
| Zdroj: | Growth Hormone & IGF Research. :45-51 |
| ISSN: | 1096-6374 |
| DOI: | 10.1016/j.ghir.2016.11.002 |
| Popis: | Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system.D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit. D3 (D, n=6) or Placebo (P, n=7). ST, a time/attention control visit, interchanged unreceptive movements. AB was moderate intensity treadmill walking. RT rotated moderate strength 50% 1-RM repetitions (15, 10) of squat, bench press, leg press, and lat pull down. Serum Total IGF1 (TIGF1), Insulin Like Growth Factor Binding Protein 1 (IGFBP1), and IGFBP3 were measured before (T1, fasting), immediately after (T2), and 2h post (T3) exercise.After ST, IGFBP3 was greater in the D group at T2 (2948, 2130ng/mL; p0.03) and T3 (3087, 2212; p0.02). During RT, TIGF1 decreased in the Placebo (P) group from T1 to T3 (151.4, 107.3ng/mL; p0.05), while IGFBP1 increased in the D group from T1 to T3 (26.5, 96.2ng/mL; p0.05). RT IGFBP3 was greater at T1, T2, and T3 in the D group (2932.5, 2110.7; p0.03), (3163.9, 2392.5; p0.04), and (3355.3, 2353.1; p0.01). In AB, IGFBP3 was greater in the D group at T2 (3128.6, 2226.3.0; p0.04) and T3 (2949.7, 2135.1; p0.05).D supplementation amplified IGFBP3 after low or moderate activity which may increase the delivery of IGF1 to tissues. Resistance exercise with D not only increased IGFBP3 and IGFBP1 levels but also conserved TIGF1 levels, possibly shifting the IGF system for enriched muscle well-being. |
| Databáze: | OpenAIRE |
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