The Prognostic Value of G1 Cyclins, p21 and Rb Protein in Patients With Colon Cancer
| Autor: | Stamatios Theocharis, Pantelis Palaiologos, Gregory Kouraklis, Dimosthenis Chrysikos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Cyclin-Dependent Kinase Inhibitor p21 Male Cancer Research Cyclin E Colorectal cancer Retinoblastoma Protein 03 medical and health sciences 0302 clinical medicine Cyclin D1 medicine Humans Survival rate Aged Cyclin Aged 80 and over Oncogene Proteins business.industry G1 Phase General Medicine Middle Aged Cell cycle Prognosis medicine.disease Neoplasm Proteins Survival Rate Ki-67 Antigen Oncology Apoptosis 030220 oncology & carcinogenesis Colonic Neoplasms Cancer research Immunohistochemistry Female business Follow-Up Studies |
| Zdroj: | Anticancer Research. 39:6291-6297 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | BACKGROUND/AIM Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor proliferation. PATIENTS AND METHODS A total of 102 patients with colon cancer were operated on and staged according to TNM. Follow-up was 2 to 68 months (mean 38.3±16.7 months). Expression of cyclin E and D1 were evaluated using immunohistochemistry. RESULTS Levels of cyclin E expression were correlated with cyclin D1 expression (p=0.038), p21 expression (p=0.047), and pRb expression (p=0.004). The 5-year survival rate along with prognosis of patients with advanced stage (III, IV) colon cancer and cyclin D1 positive tumors, were significantly worse (p=0.009). Statistically significant association was observed between tumor proliferative capacity Ki-67, cyclin D1 (p=0.009), pRb (p=0.031) and p21 (p=0.050). CONCLUSION Cyclin D1 is highly expressed in advanced stage colon cancer patients, implying a potential prognostic value. |
| Databáze: | OpenAIRE |
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